3D DNAzyme Motor Nanodevice With Self‐Powered FRET Amplifier and Self‐Supplied H2O2 for Enhancing Human Neutrophil Elastase Profiling and Chemodynamic Therapy in Lung Tumor
Huiyan Du,
Ensheng Xu,
Yihan Xu
et al.
Abstract:The development of theragnostic nanosystems integrating FRET (fluorescence resonance energy transfer) imaging and chemodynamic therapy (CDT) for accurate diagnosis and effective treatment of lung tumors is still a big challenge. Herein, a peptide‐assembled 3D DNAzyme motor nanodevice is engineered for a self‐powered FRET amplifier profiling human neutrophil elastase (HNE) and self‐supplied H2O2 enhancing CDT. The nanodevice is prepared by depositing AuNPs on ZIF‐8, in which ZIF‐8 co‐loaded the lysosomal target… Show more
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