3D DNA Origami Cuboids as Monodisperse Patchy Nanoparticles for Switchable Hierarchical Self-Assembly

Tigges, Thomas; Heuser, Thomas; Tiwari, Rahul; Walther, Andreas

doi:10.1021/acs.nanolett.6b04146

Cited by 72 publications

(77 citation statements)

References 32 publications

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“…However,t hey can serve to precisely attach and arrange inorganic nanoparticles. [211,212] Besides the development of further aerogel materials and to take the existing results to alarger scale,this field has now the potential to focus on amore targeted progress.T aking the library of available nanoparticles and assembling them into aerogels allows for as pecific tuning of their final properties. [208,209] TheS eidel group even showed that the inorganic nanostructures obtained still have an intact DNAshell, which makes it possible to assemble them in acontrolled manner.…”

Section: Discussionmentioning

confidence: 99%

Modern Inorganic Aerogels

et al. 2017

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Essentially, the term aerogel describes a special geometric structure of matter. It is neither limited to any material nor to any synthesis procedure. Hence, the possible variety of materials and therefore the multitude of their applications are almost unbounded. In fact, the same applies for nanoparticles. These are also just defined by their geometrical properties. In the past few decades nano-sized materials have been intensively studied and possible applications appeared in nearly all areas of natural sciences. To date a large variety of metal, semiconductor, oxide, and other nanoparticles are available from colloidal synthesis. However, for many applications of these materials an assembly into macroscopic structures is needed. Here we present a comprehensive picture of the developments that enabled the fusion of the colloidal nanoparticle and the aerogel world. This became possible by the controlled destabilization of pre-formed nanoparticles, which leads to their assembly into three-dimensional macroscopic networks. This revolutionary approach makes it possible to use precisely controlled nanoparticles as building blocks for macroscopic porous structures with programmable properties.

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Section: Discussionmentioning

confidence: 99%

Modern Inorganic Aerogels

et al. 2017

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“…[64] The topography of the patterned substrate provided a sufficient bias to control the long-range order of the block copolymer. [70][71][72][73] When the DNA assembly is precisely controlled by using a patterned surface, DNA origami can be a powerful tool, for example, by dictating the arrangement of sub 10 nm components (gold nanoparticles) over large scale areas ( Figure 2C). [63][64][65][66] Template-directed assembly of molecules, DNA, and nanoparticles can also give rise to micro and nanoscale structures with promising optical responses.…”

Section: Wwwadvopticalmatdementioning

confidence: 99%

Template‐Directed Solidification of Eutectic Optical Materials

Kulkarni

Kohanek

Tyler

et al. 2018

Advanced Optical Materials

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polarizers, some waveguides, and many lasers. [1][2][3] Materials with powerful optical functionalities, including negative-index of refraction and optical chirality, can be realized by appropriate placement of materials with suitable properties in 2D or 3D space. [4][5][6] Light in the visible spectrum can be manipulated, although the tolerance for defects is exceedingly low at visible frequencies, and the number of materials with the appropriate properties is limited. [7,8] Most photonic crystals are fabricated by high-resolution top-down 2D patterning methods such as electron-beam lithography, interference lithography, and focused ion beam milling. [9] However, it is challenging to fabricate large-area bulk materials with these techniques, especially with intricate internal structures. [8] Additionally, many materials with promising optical properties are not compatible with these top-down patterning methods. [4,10] As work on colloidal crystals has shown, controlled self-assembly is an effective route to organizing materials into 3D architectures, which interact strongly with light. [9][10][11][12][13] Colloidal self-assembly, however, only offers a limited set of symmetries (generally those of close packed arrangements), and a spherical basis. [12] For many applications, considerably more complex structures are of interest. Particularly promising approaches for forming materials with complex internal microstructures include eutectic solidification and block copolymer self-assembly, [14][15][16][17] and materials with interesting optical properties have been reported using both approaches. These methods are advantageous due to the wide range of microstructures they form. Here, we focus on the structures formed by eutectic solidification since materials with a broader range of optical properties are available compared to that provided by block copolymers, and because the characteristic lengths of structures accessible through eutectic solidification better match the wavelengths of visible and IR light. Further, forming materials with sufficiently large characteristic dimensions for interaction with visible light by block copolymer assembly is synthetically challenging as it requires high molecular weight polymers. [18] Similarly, self-assembly of other building blocks, e.g., nanoparticles, [19,20] molecules, [21,22] and DNA, [23,24] tend to produce structures with characteristic dimensions too small to provide strong light-matter interactions (via diffractive phenomena), [2,3,25] and are thus not the emphasis of this review.Mesostructured materials can exhibit enhanced light-matter interactions, which can become particularly strong when the characteristic dimensions of the structure are similar to or smaller than the wavelength of light. For controlling visible to near-infrared wavelengths, the small characteristic dimensions of the required structures usually demand fabrication by sophisticated lithographic techniques. However, these fabrication methods are restricted to producing 2D and a limited range of 3D...

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“…As the monodisperse nanoparticle, we employ a bivalent 3D DNA origami cuboid . It is folded from a m13mp18 cyclic scaffold ssDNA and a 5‐fold excess of ssDNA staple strands in a temperature ramp and purified by membrane spin‐filtration to remove excess staple strands (Figure a).…”

Section: Figurementioning

confidence: 99%

Supracolloidal Self‐Assembly of Divalent Janus 3D DNA Origami via Programmable Multivalent Host/Guest Interactions

Loescher

Walther

2020

Angew Chem Int Ed

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We introduce divalent 3D DNA origami cuboids as truly monodisperse colloids and harness their ability for precision functionalization with defined patches and defined numbers of supramolecular binding motifs. We demonstrate that even adamantane/β‐cyclodextrin host/guest inclusion complexes of moderate association strength can induce efficient supracolloidal fibrillization at high dilution of the 3D DNA Origami as a result of cooperative multivalency. We show details on the assembly of Janus and non‐Janus 3D DNA origami into supracolloidal homo‐ and heterofibrils with respect to multivalency effects, electrostatic screening, and stoichiometry. We believe that the merger of 3D DNA origami with colloidal self‐assembly and supramolecular motifs provides new synergies at the interface of these disciplines to better understand multivalency effects, to promote structural complexity, and add non‐DNA assembling and switching mechanisms to DNA nanoscience.

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3D DNA Origami Cuboids as Monodisperse Patchy Nanoparticles for Switchable Hierarchical Self-Assembly

Cited by 72 publications

References 32 publications

Modern Inorganic Aerogels

Modern Inorganic Aerogels

Template‐Directed Solidification of Eutectic Optical Materials

Supracolloidal Self‐Assembly of Divalent Janus 3D DNA Origami via Programmable Multivalent Host/Guest Interactions

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