3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma

Ren, Yu; Gao, Yuanhong; Cao, Xin; Ye, Wei Jun; Teh, Bin S.

doi:10.1186/1748-717x-5-113

Cited by 13 publications

(13 citation statements)

References 34 publications

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“…It is possible to enhance outcome results because of the local dose escalation in the case of larger primary tumor masses (36,37); however, according to the presented results, the combination of debulking surgery and perioperative intensity-modulated brachytherapy seems to represent a feasible method in the treatment of eligible recurrent sinonasal and nasopharyngeal cancers.…”

Section: Discussionmentioning

confidence: 72%

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

et al. 2015

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Section: Discussionmentioning

confidence: 72%

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

et al. 2015

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“…Clinical results are summarized in Table 4. 71,72,78,[82][83][84][85][86][87][88][89][90] As can be observed, the outcome of patients treated with brachytherapy appears superior to that of patients treated with EBRT alone without increased toxicity. Of course, the difference may be due to a selection bias as T3 and T4 patients are not candidate to brachytherapy.…”

Section: Brachytherapymentioning

confidence: 60%

Review of photon and proton radiotherapy for skull base tumours

Fossati

Vavassori²,

Deantonio

et al. 2016

Reports of Practical Oncology & Radiotherapy

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a b s t r a c tAn extremely large variety of benign and malignant tumours occur at skull base; these tumour lesions are in the proximity to structures deputed to relevant physiologic functions, limiting extensive surgical approaches to this body district. Most recent progresses of surgery and radiotherapy have allowed to improve local control with acceptable rates of side effects. Various photon radiotherapy techniques are employed, including 3-dimensional conformal radiotherapy, intensity modulated radiotherapy (IMRT), stereotactic radiotherapy (SRT) and brachytherapy that is manly limited to the treatment of primary or recurrent nasopharyngeal carcinoma. Proton beam radiotherapy is also extensively used thanks to its physical characteristics. Our review, focusing in particular on meningioma, chordoma, and chondrosarcoma, suggests that proton therapy plays a major role in the treatment of malignant tumours whereas photon therapy still plays a relevant role in the treatment of benign tumour lesions.

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“…Retrospective analysis of the two groups showed that five patients with stage T2b disease who developed local recurrence were in the arm of 2D brachytherapy. The role of brachytherapy in patients with stage T2b disease is controversial [ 9 , 21 ]. Levendag et al [ 22 ] reported that some patients with stage T2b NPC lesions may benefit from dose-escalation by brachytherapy boost when the tumor had regressed to the clinical target volume after EBRT pretreatment.…”

Section: Discussionmentioning

confidence: 99%

3D-image-guided HDR-brachytherapy versus 2D HDR - brachytherapy after external beam radiotherapy for early T-stage nasopharyngeal carcinoma

et al. 2014

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BackgroundTwo-dimensional high-dose-rate brachytherapy (2D-HDR-BT) is an effective method of dose escalation for local tumor control in early T-stage nasopharyngeal carcinoma (NPC). Treatment outcomes for 3D-image-guided high-dose-rate brachytherapy (3D-image-guided-HDR-BT) after external beam radiotherapy (ERT) have not been examined in early T-stage NPC patients. The current study was designed to evaluate whether addition of 3D-HDR-BT to ERT showed further improvement in treatment outcomes in patients with early T-stage NPC when compared to 2D-HDR-BT after ERT.MethodsThe current study retrospectively analyzed and compared treatment outcomes for patients with nonmetastatic stage T1-2b NPC treated with 2D-HDR-BT (n =101) or 3D-HDR-BT (n =118) after ERT. Patients in both groups were treated with ERT at a mean dose of 60 Gy and a brachytherapy dose of 12Gy (8 ~ 20Gy), 2.5 ~ 5Gy per fraction under local anesthesia.ResultsCompared to patients treated with 2D-HDR-BT after ERT, patients treated with 3D-HDR-BT after ERT showed improvement in five-year actuarial local control survival rates (p = 0.024), local/regional relapse-free survival rates (p = 0.038), and disease-free survival rates (p = 0.021). Multivariate analysis showed that NPC patients treated with 3D-HDR-BT had improved local control survival (p = 0.042). The incidence rates of acute or chronic complications were similar between two groups.ConclusionsThe current study showed that 3D-image-guided HDR-BT after ERT was an effective treatment modality for patients with stage T1-2 NPC with acceptable complications. The improvement in local tumor control and disease free survival is likely due to improved conformal dose distributions.

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3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma

Cited by 13 publications

References 34 publications

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

Review of photon and proton radiotherapy for skull base tumours

3D-image-guided HDR-brachytherapy versus 2D HDR - brachytherapy after external beam radiotherapy for early T-stage nasopharyngeal carcinoma

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