3D control stretched length of lambda-phage WLC DNA molecule by nonlinear optical tweezers

Manh, Thang Nguyen; Quang, Quy Ho; Doan, Thanh Thai; Quoc, Tuan Doan; Thanh, Viet Do; Khoa, Doan Quoc

doi:10.1007/s11082-019-2164-6

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…One of the key contributing effects affecting the optical manipulation of nano‐ and micro‐objects is thermal noise. [ 13 , 14 ] Fluctuations affect particle‐environment interactions, [ 15 , 16 ] imposing additional constraints on optical tweezing in biological media. [ 17 ] Furthermore, temperature gradients in an embedding fluid give rise to directional thermophoretic forces acting on small particles.…”

Section: Introductionmentioning

confidence: 99%

Optothermal Needle‐Free Injection of Vaterite Nanocapsules

Kislov,

Ofer,

Machnev

et al. 2023

Advanced Science

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The propulsion and acceleration of nanoparticles with light have both fundamental and applied significance across many disciplines. Needle‐free injection of biomedical nano cargoes into living tissues is among the examples. Here a new physical mechanism of laser‐induced particle acceleration is explored, based on abnormal optothermal expansion of mesoporous vaterite cargoes. Vaterite nanoparticles, a metastable form of calcium carbonate, are placed on a substrate, underneath a target phantom, and accelerated toward it with the aid of a short femtosecond laser pulse. Light absorption followed by picosecond‐scale thermal expansion is shown to elevate the particle's center of mass thus causing acceleration. It is shown that a 2 µm size vaterite particle, being illuminated with 0.5 W average power 100 fsec IR laser, is capable to overcome van der Waals attraction and acquire 15m sec−1 velocity. The demonstrated optothermal laser‐driven needle‐free injection into a phantom layer and Xenopus oocyte in vitro promotes the further development of light‐responsive nanocapsules, which can be equipped with additional optical and biomedical functions for delivery, monitoring, and controllable biomedical dosage to name a few.

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Section: Introductionmentioning

confidence: 99%

Optothermal Needle‐Free Injection of Vaterite Nanocapsules

Kislov,

Ofer,

Machnev

et al. 2023

Advanced Science

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Optimization of nonlinear optical tweezers suitable to stretch DNA molecules without broken state

et al. 2020

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Optical bistability of partial reflection-coated thin film of oil red O

et al. 2020

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In this paper, a thin film of oil red O coated by partial dielectric mirrors (PRFORO) operating as an optical bistable device is proposed. The equation of the output–input intensity relation considering nonlinear absorption inside PRFORO is derived and the optical bistability (OB) of PRFORO is shown. Additionally, the influence of the nonlinear refractive, absorptive coefficients of oil red O (ORO), reflective coefficient of mirrors, and the thickness of thin film on the OB is numerically investigated and discussed. As a result, the threshold switching power is lower than 19 mW; the minimum power of output up-state is larger than 40 µW for the optimal PRFORO designed with an ORO concentration larger than 0.1 mM; the thickness of the thin film is longer than 0.1 mm; and the reflective coefficient of mirrors is lower than 93%. The proposed model is suitable for all-optical switches, optical images, and signal processing.

show abstract

3D control stretched length of lambda-phage WLC DNA molecule by nonlinear optical tweezers

Cited by 4 publications

References 21 publications

Optothermal Needle‐Free Injection of Vaterite Nanocapsules

Optothermal Needle‐Free Injection of Vaterite Nanocapsules

Optimization of nonlinear optical tweezers suitable to stretch DNA molecules without broken state

Optical bistability of partial reflection-coated thin film of oil red O

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