3D-conformal-intensity modulated radiotherapy with compensators for head and neck cancer: clinical results of normal tissue sparing

Wendt, Thomas; Abbasi-Senger, N.; Salz, Henning; Pinquart, Ines; Koscielny, Sven; Wiezorek, Tilo

doi:10.1186/1748-717x-1-18

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…The motivation behind improved beam angle selection stems from the continued need to decrease the dose to critical organs. This need is validated by clinical studies that show decreased toxicity is associated with lower critical organ doses (Marmiroli et al 2005, Wendt et al 2006, Arcangeli et al 2007, Kuban et al 2008. While we have not explicitly addressed the issue in this paper, as tumor dose-response relationships continue to be validated through clinical trials, the need for addressing critical organ toxicity assumes greater significance.…”

Section: Discussionmentioning

confidence: 93%

A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

et al. 2008

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Coupling beam angle optimization with dose optimization in intensity-modulated radiation therapy (IMRT) increases the size and complexity of an already large-scale combinatorial optimization problem. We have developed a novel algorithm, nested partitions (NP), that is capable of finding suitable beam angle sets by guiding the dose optimization process. NP is a metaheuristic that is flexible enough to guide the search of a heuristic or deterministic dose optimization algorithm. The NP method adaptively samples from the entire feasible region, or search space, and coordinates the sampling effort with a systematic partitioning of the feasible region at successive iterations, concentrating the search in promising subsets. We used a 'warm-start' approach by initiating NP with beam angle samples derived from an integer programming (IP) model. In this study, we describe our implementation of the NP framework with a commercial optimization algorithm. We compared the NP framework with equi-spaced beam angle selection, the IP method, greedy heuristic and random sampling heuristic methods. The results of the NP approach were evaluated using two clinical cases (head and neck and whole pelvis) involving the primary tumor and nodal volumes. Our results show that NP produces better quality solutions than the alternative considered methods.

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Section: Discussionmentioning

confidence: 93%

A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

et al. 2008

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“…Preventive strategies of salivary gland hypofunction and dry mouth secondary to RT have focused on the preservation of salivary gland function, primarily the parotid glands, by new advances in radiation techniques, including the appearance and optimizing of 3D treatment planning, conformal radiation techniques, and intensity-modified radiotherapy (IMRT) [ 20 , 21 ]. Recent studies also showed that the prevention of hyposalivation secondary to RT may be addressed via use of cytoprotective agents (eg.…”

Section: Sgd Secondary To Cancer Treatmentmentioning

confidence: 99%

Salivary Gland Dysfunction Secondary to Cancer Treatment

Monreal

Polonsky

Shiboski

et al. 2022

Front. Oral. Health

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The number of cancer survivors are increasing and so are the oral toxicities from cancer therapy. Most patients receiving treatment for cancer develop some form of oral adverse events including, but not limited to, mucositis, opportunistic infections, dry mouth, and/or osteonecrosis of the jaw. One of the most common complications from head and neck cancer radiation therapy is salivary gland dysfunction (SGD). SGD is an umbrella term that includes the subjective sensation of dry mouth (xerostomia) and hyposalivation (objective reduction of the salivary flow rate). Dry mouth in cancer patients may lead to functional defects (e.g., eating, speaking, and swallowing), increase the risk of dental caries and oral candidiasis, and can have a negative effect on the nutritional and psychological status of the patients. The aim of this mini review was to summarize the current criteria for diagnosis and management of SGD associated with cancer treatment.

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A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life

Jensen

Pedersen

Vissink

et al. 2010

Support Care Cancer

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Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.

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3D-conformal-intensity modulated radiotherapy with compensators for head and neck cancer: clinical results of normal tissue sparing

Abstract: Background: To investigate the potential of parotic gland sparing of intensity modulated radiotherapy (3D-c-IMRT) performed with metallic compensators for head and neck cancer in a clinical series by analysis of dose distributions and clinical measures.

Cited by 6 publications

References 22 publications

A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

Salivary Gland Dysfunction Secondary to Cancer Treatment

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life

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