3D bioprinting of cardiac tissue: current challenges and perspectives

Kato, Brian; Wisser, Gary; Agrawal, Devendra K.; Wood, Timothy J.; Thankam, Finosh G.

doi:10.1007/s10856-021-06520-y

Cited by 42 publications

(28 citation statements)

References 68 publications

(36 reference statements)

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“…Bioprinting is the future of 3D printing technology in medical applications, with significant progress made in printing cardiovascular constructs, cardiovascular regeneration and pharmacology over the last decades [ 94 , 95 , 96 , 97 , 98 , 99 ]. Figure 15 outlines the scheme of 3D bioprinting technology in the cardiovascular system.…”

Section: Limitations Barriers and Future Directionsmentioning

confidence: 99%

3D Printed Models in Cardiovascular Disease: An Exciting Future to Deliver Personalized Medicine

Sun

Wee

2022

Micromachines

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3D printing has shown great promise in medical applications with increased reports in the literature. Patient-specific 3D printed heart and vascular models replicate normal anatomy and pathology with high accuracy and demonstrate superior advantages over the standard image visualizations for improving understanding of complex cardiovascular structures, providing guidance for surgical planning and simulation of interventional procedures, as well as enhancing doctor-to-patient communication. 3D printed models can also be used to optimize CT scanning protocols for radiation dose reduction. This review article provides an overview of the current status of using 3D printing technology in cardiovascular disease. Limitations and barriers to applying 3D printing in clinical practice are emphasized while future directions are highlighted.

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Section: Limitations Barriers and Future Directionsmentioning

confidence: 99%

3D Printed Models in Cardiovascular Disease: An Exciting Future to Deliver Personalized Medicine

Sun

Wee

2022

Micromachines

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“…In addition, if autologous cells are used, the immune response is less likely to be stimulated. [ 18 ] Despite the advantages of 3D bioprinting, it faces several challenges, such as lack of availability of polymers, poor adhesion, viability, and short life of bioinks. [ 19 ] However, the use of nanotechnology in the 3D printing of heart tissues can play a momentous role in this regard.…”

Section: Current Status Of Cardiac Tissue Engineeringmentioning

confidence: 99%

Conductive and Semiconductive Nanocomposite‐Based Hydrogels for Cardiac Tissue Engineering

Alamdari

Alibakhshi

Guárdia

et al. 2022

Adv Healthcare Materials

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Cardiovascular disease is the leading cause of death worldwide and the most common cause is myocardial infarction. Therefore, appropriate approaches should be used to repair damaged heart tissue. Recently, cardiac tissue engineering approaches have been extensively studied. Since the creation of the nature of cardiovascular tissue engineering, many advances have been made in cellular and scaffolding technologies. Due to the hydrated and porous structures of the hydrogel, they are used as a support matrix to deliver cells to the infarct tissue. In heart tissue regeneration, bioactive and biodegradable hydrogels are required by simulating native tissue microenvironments to support myocardial wall stress in addition to preserving cells. Recently, the use of nanostructured hydrogels has increased the use of nanocomposite hydrogels and has revolutionized the field of cardiac tissue engineering. Therefore, to overcome the limitation of the use of hydrogels due to their mechanical fragility, various nanoparticles of polymers, metal, and carbon are used in tissue engineering and create a new opportunity to provide hydrogels with excellent properties. Here, the types of synthetic and natural polymer hydrogels, nanocarbon-based hydrogels, and other nanoparticle-based materials used for cardiac tissue engineering with emphasis on conductive nanostructured hydrogels are briefly introduced.

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“…The extrusion-based 3D printing is a facile, less complex and affordable 3D printing approach (Mandrycky et al, 2016;Kato et al, 2021). The cell deposition density usually ranges from 10 8 -10 9 cells per mL which is crucial for cardiac tissue engineering (Pati et al, 2014).…”

Section: Extrusion-based 3d Bioprintingmentioning

confidence: 99%

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

Chingale

Cheng

2022

Front. Mater.

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Cardiovascular diseases are one of the leading causes of death across the globe. Heart transplantation has been used for end stage heart failure patients. However, due to the lack of donors, this treatment option usually depends on multiple variables and the result varies due to immunological issues. 3D bioprinting is an emerging approach for in vitro generation of functional cardiac tissues for drug screening and cardiac regenerative therapy. There are different techniques such as extrusion, inkjet, or laser-based 3D printing that integrate multiple cell lines with different scaffolds for the construction of complex 3D structures. In this review, we discussed the recent progress and challenges in 3D bioprinting strategies for cardiac tissue engineering, including cardiac patches, in vitro cardiac models, valves, and blood vessels.

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3D bioprinting of cardiac tissue: current challenges and perspectives

Cited by 42 publications

References 68 publications

3D Printed Models in Cardiovascular Disease: An Exciting Future to Deliver Personalized Medicine

3D Printed Models in Cardiovascular Disease: An Exciting Future to Deliver Personalized Medicine

Conductive and Semiconductive Nanocomposite‐Based Hydrogels for Cardiac Tissue Engineering

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

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