3D bioprinting for artificial cornea: Challenges and perspectives

Zhang, Bin; Xue, Qingwu; Li, Jintao; Ma, Liang; Yao, Yufeng; Ye, Hua; Cui, Zhanfeng; Yang, Huayong

doi:10.1016/j.medengphy.2019.05.002

Cited by 71 publications

(82 citation statements)

References 92 publications

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“…Availability of artificial corneas and 3D-bioprinted corneas may have proved to be of immense importance during this health emergency, however, these are still under research. [ 17 18 ]…”

Section: Discussionmentioning

confidence: 99%

To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute

Babu

Kohli

Mishra

et al. 2020

Indian J Ophthalmol

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Purpose: To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute. Methods: Records of all the patients who presented from March 25 th to May 3 rd , 2020 were scanned to evaluate the details regarding the presenting complaints, diagnosis, advised treatment and surgical interventions. Results: The number of outpatient department visits, retinal laser procedures, intravitreal injections and cataract surgeries during this lockdown decreased by 96.5%, 96.5%, 98.7% and 99.7% respectively compared from the corresponding time last year. Around 38.8% patients could be triaged as non-emergency cases based on history alone while 59.5% patients could be triaged as non-emergency cases after examination. Only eighty-four patients opted for video-consultation from April 15 th to May 3 rd , 2020. Nine patients presented with perforated corneal ulcer, but could not undergo penetrating keratoplasty due to the lack to available donor corneal tissue. One of these patients had to undergo evisceration due to disease progression. Two patients with open globe injury presented late after trauma and had to undergo enucleation. Around 9% patients could not undergo the advised urgent procedure due to logistical issues related to the lockdown. Conclusion: A significant number of patients could not get adequate treatment during the lockdown period. Hospitals need to build capacity to cater to the expected patient surge post-COVID-19-era, especially those requiring immediate in-person attention. A large number of patients can be classified as non-emergency cases. These patients need to be encouraged to follow-up via video-consultation to carve adequate in-person time for the high-risk patients.

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“…Availability of artificial corneas and 3D-bioprinted corneas may have proved to be of immense importance during this health emergency, however, these are still under research. [ 17 18 ]…”

Section: Discussionmentioning

confidence: 99%

To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute

Babu

Kohli

Mishra

et al. 2020

Indian J Ophthalmol

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“…As an alternative to cadaveric corneas, among others, the dECM from acellular porcine and bovine cornea and decellularized amniotic membrane have been combined with different cell types to form full-thickness corneas with stroma, epithelium, and endothelium layers [178][179][180]. This dECM replicates the structure and functional requirements of the native cornea, with the maintenance of the collagen fibril organization, transparency, biocompatibility, suitable mechanical toughness, and low immunogenicity [181,182].…”

Section: Corneamentioning

confidence: 99%

Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds

Mendibil

Ruiz-Hernández

Retegi-Carrión

et al. 2020

IJMS

183

187

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The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. This review provides an overview of the most common methods used to obtain the dECM and summarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guide for future research development.

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“…A full-thickness structure with both optical and biological properties is the aim of cornea substitute development. Reprinted from Zhang et al (2019), Copyright 2019, with permission from Elsevier the outer shell portion of the structure with a certain thickness is constructed using the extrusion printing module. Accurate geometric characteristic construction and multi-material combinations are the main advantages of 3D bioprinting technology (Ahadian and Khademhosseini, 2018).…”

Section: Fig 1 Schematic Of Corneal Substitute Developmentmentioning

confidence: 99%

Integrated 3D bioprinting-based geometry-control strategy for fabricating corneal substitutes

Zhang

Xue

et al. 2019

J. Zhejiang Univ. Sci. B

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Background: The shortage of donor corneas is a severe global issue, and hence the development of corneal alternatives is imperative and urgent. Although attempts to produce artificial cornea substitutes by tissue engineering have made some positive progress, many problems remain that hamper their clinical application worldwide. For example, the curvature of tissue-engineered cornea substitutes cannot be designed to fit the bulbus oculi of patients. Objective: To overcome these limitations, in this paper, we present a novel integrated three-dimensional (3D) bioprintingbased cornea substitute fabrication strategy to realize design, customized fabrication, and evaluation of multi-layer hollow structures with complicated surfaces. Methods: The key rationale for this method is to combine digital light processing (DLP) and extrusion bioprinting into an integrated 3D cornea bioprinting system. A designable and personalized corneal substitute was designed based on mathematical modelling and a computer tomography scan of a natural cornea. The printed corneal substitute was evaluated based on biomechanical analysis, weight, structural integrity, and fit. Results: The results revealed that the fabrication of high water content and highly transparent curved films with geometric features designed according to the natural human cornea can be achieved using a rapid, simple, and low-cost manufacturing process with a high repetition rate and quality. Conclusions: This study demonstrated the feasibility of customized design, analysis, and fabrication of a corneal substitute. The programmability of this method opens up the possibility of producing substitutes for other cornea-like shell structures with different scale and geometry features, such as the glomerulus, atrium, and oophoron.

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3D bioprinting for artificial cornea: Challenges and perspectives

Cited by 71 publications

References 92 publications

To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute

To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute

Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds

Integrated 3D bioprinting-based geometry-control strategy for fabricating corneal substitutes

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