3D Bioprinting: A Novel Avenue for Manufacturing Tissues and Organs

Zhang, Bin; Gao, Lei; Ma, Liang; Luo, Yichen; Yang, Huayong; Cui, Zhanfeng

doi:10.1016/j.eng.2019.03.009

Cited by 154 publications

(119 citation statements)

References 154 publications

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“…Bioinks useful to obtain effective bone substitutes require properties including biocompatibility, biomimicry, biodegradability, bioprintability, and mechanical integrity [ 31 , 32 ]. Thus, the design of the appropriate bioink is probably the main challenge of bioprinting [ 33 , 34 ]. For instance, parameters such as bioink viscosity, the effects of pressure, temperature, nozzle size, crosslinking methods on bioinks, and the macrostructure/geometry of the material (i.e., porosity) are major concerns for the successful production of bone tissue [ 35 , 36 ].…”

Section: Bioprintingmentioning

confidence: 99%

“…DBB presents several advantages such as the high printing speed and relative low costs [ 162 ]. The main applications of DBB technology regard skin [ 171 ], cartilage [ 172 ], bone [ 173 , 174 ] and blood vessels bioprinting [ 34 , 175 , 176 ]. Bone-like structures have been produced using the IBB technology, which allows HA and tricalcium phosphate droplets deposition onto powders [ 34 , 173 , 174 ].…”

Section: Bioprinting Processmentioning

confidence: 99%

“…Using thermal-IBB Gao et al [ 34 ] produced poly(ethylene glycol) dimethacrylate scaffolds supplemented with HA and osteoinductive ceramics co-printed with bone-marrow-derived human mesenchymal stem cells (BMSCs). This technique presented significant advantages compared to manually pipetted BMSCs, such as an even and 3D homogeneous BMSCs distribution.…”

Section: Bioprinting Processmentioning

confidence: 99%

“…The third method for 3D-bioprinting is Light-Based Bioprinting (LBB), also commonly referred to as laser-based bioprinting. LBB, which includes laser-assisted printing and stereolithography, configures as the fastest and most resolute method among all bioprinting strategies, with no limitations associated with the material viscosity [ 34 , 178 , 179 ].…”

Section: Bioprinting Processmentioning

confidence: 99%

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Advances on Bone Substitutes through 3D Bioprinting

Genova

Roato

Carossa

et al. 2020

IJMS

101

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Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

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Section: Bioprintingmentioning

confidence: 99%

Section: Bioprinting Processmentioning

confidence: 99%

Section: Bioprinting Processmentioning

confidence: 99%

Section: Bioprinting Processmentioning

confidence: 99%

See 2 more Smart Citations

Advances on Bone Substitutes through 3D Bioprinting

Genova

Roato

Carossa

et al. 2020

IJMS

101

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“…As such, 3D cell printing is a powerful technology for constructing tissue-engineered tissue/organs. Moreover, 3D patterning of cells and biomolecules enables the fabrication of complex structures of customized sizes that mimic native organs [ 143 ]. Many researchers have investigated the therapeutic application of 3D cell printing for regenerative medicine.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications

Kim

Kong

Han

et al. 2020

IJMS

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The development of artificial tissue/organs with the functional maturity of their native equivalents is one of the long-awaited panaceas for the medical and pharmaceutical industries. Advanced 3D cell-printing technology and various functional bioinks are promising technologies in the field of tissue engineering that have enabled the fabrication of complex 3D living tissue/organs. Various requirements for these tissues, including a complex and large-volume structure, tissue-specific microenvironments, and functional vasculatures, have been addressed to develop engineered tissue/organs with native relevance. Functional tissue/organ constructs have been developed that satisfy such criteria and may facilitate both in vivo replenishment of damaged tissue and the development of reliable in vitro testing platforms for drug development. This review describes key developments in technologies and materials for engineering 3D cell-printed constructs for therapeutic and drug testing applications.

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