3D Bioprinted Highly Elastic Hybrid Constructs for Advanced Fibrocartilaginous Tissue Regeneration

Costa, João B.; Park, Jihoon; Jorgensen, Adam; Silva‐Correia, Joana; Reis, Rui L.; Oliveira, Joaquím M.; Atala, Anthony; Yoo, James J.; Lee, Sang Jin

doi:10.1021/acs.chemmater.0c03556

Cited by 48 publications

(53 citation statements)

References 68 publications

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“…Interestingly, hybrid approaches have been explored showing promising achievements with respect to simultaneously addressing mechanical and biological functions. [ 87 ]…”

Section: Scaffolding Fabrication Methodsmentioning

confidence: 99%

Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Collins

Ren

Young

et al. 2021

Adv Funct Materials

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496

254

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Bone tissue engineering (BTE) is a rapidly growing field aiming to create a biofunctional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue. It has become evident that scaffold fabrication techniques are very important in dictating the final structural, mechanical properties, and biological response of the implanted biomaterials. A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided herein. Different types of biomaterials ranging from inorganic biomaterials to natural and synthetic polymers and related composites for scaffold processing are presented. Emergent scaffolding techniques such as electrospinning, freeze-drying, bioprinting, and decellularization are also discussed. Strategies to improve vascularization potential and immunomodulation, which is considered a grand challenge in BTE scaffolding, are also presented.

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“…Interestingly, hybrid approaches have been explored showing promising achievements with respect to simultaneously addressing mechanical and biological functions. [ 87 ]…”

Section: Scaffolding Fabrication Methodsmentioning

confidence: 99%

Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Collins

Ren

Young

et al. 2021

Adv Funct Materials

Self Cite

496

254

View full text Add to dashboard Cite

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“…Three-dimensional (3D)-printed biomaterial constructs have been tried to generate different human tissues, including meniscus 10 - 13 .…”

Section: Introductionmentioning

confidence: 99%

3D-bioprinting ready-to-implant anisotropic menisci recapitulate healthy meniscus phenotype and prevent secondary joint degeneration

Sun¹,

Zhang²,

Wu³

et al. 2021

Theranostics

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Objectives: Disruption of anisotropic phenotypes of the meniscus would contribute to OA progression. Exploring phenotype changes of the anisotropic meniscus in joint degeneration would help understand the biologic interaction between the meniscus and OA, and further facilitate the therapeutic strategies of meniscus injury-related joint degeneration. Meanwhile, engineering biomimetic meniscal tissue mimicking the anisotropy of the healthy meniscus remains a challenge. Methods & Results: Meniscal disruption of phenotype anisotropy (PBV growth, cellular phenotype and ECM depositions) was confirmed in OA patient samples. To recapitulate healthy meniscus phenotypes, 3D-bioprinted anisotropic TCM meniscus constructs with PBV growth and regional differential cell and ECM depositions were generated. Transplanted 3D-bioprinted meniscus into rabbit knees recapitulated phenotypes of native healthy meniscus and conferred long-term protection against secondary joint degeneration. Conclusion: 3D-bioprinted TCM meniscus not only restored the anisotropy of native healthy meniscus with PBV infiltration and better shape retention, but better maintained joint function and prevented secondary joint degeneration, which provided a new strategy for the clinical treatment of meniscus injury-related joint degenerative diseases.

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“…Romanazzo et al 137 mixed alginate with meniscal dECM (crosslinking by 48/92 mM CaCl 2 ). Other composite cell-laden bioink formulations were that reported by Sun et al, 136 using gelatin + fibrinogen + hyaluronic acid + glycerol incapsulating PLGA microparticles carrying TGFβ3 or CTGF; Jian et al, 135 combining GelMA with pig meniscal dECM (crosslinking by blue light, 405 nm); Costa et al, 139 proposing a sequential co-printing gellan gum/fibrinogen + porcine meniscus cells and SF methacrylate: here, gellan gum and fibrinogen lead to a stable hydrogel by a combination of ionic and enzymatic cross-linking while SF methacrylate lead to beta-sheet formation along culture time.…”

Section: Bioinks Formulations and Critical Issuesmentioning

confidence: 99%

“…According to our knowledge, only Costa et al 139 reported its use in a complex bioink formulation for 3D bioprinted meniscal scaffolds fabrication.…”

Section: Synthetic and Natural Materials For Meniscal Scaffolds Printing Conditioning And Bioprintingmentioning

confidence: 99%

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Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

et al. 2022

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Meniscal tears are a frequent orthopedic injury commonly managed by conservative strategies to avoid osteoarthritis development descending from altered biomechanics. Among cutting-edge approaches in tissue engineering, 3D printing technologies are extremely promising guaranteeing for complex biomimetic architectures mimicking native tissues. Considering the anisotropic characteristics of the menisci, and the ability of printing over structural control, it descends the intriguing potential of such vanguard techniques to meet individual joints’ requirements within personalized medicine. This literature review provides a state-of-the-art on 3D printing for meniscus reconstruction. Experiences in printing materials/technologies, scaffold types, augmentation strategies, cellular conditioning have been compared/discussed; outcomes of pre-clinical studies allowed for further considerations. To date, translation to clinic of 3D printed meniscal devices is still a challenge: meniscus reconstruction is once again clear expression of how the integration of different expertise (e.g., anatomy, engineering, biomaterials science, cell biology, and medicine) is required to successfully address native tissues complexities.

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3D Bioprinted Highly Elastic Hybrid Constructs for Advanced Fibrocartilaginous Tissue Regeneration

Cited by 48 publications

References 68 publications

Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

3D-bioprinting ready-to-implant anisotropic menisci recapitulate healthy meniscus phenotype and prevent secondary joint degeneration

Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

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