3D biofabrication for soft tissue and cartilage engineering

Turnbull, Gareth; Clarke, Jon; Picard, F.; Zhang, Weidong; Riches, Philip; Li, Bin; Shu, Wenmiao

doi:10.1016/j.medengphy.2020.06.003

Cited by 30 publications

(44 citation statements)

References 265 publications

(2 reference statements)

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“…In the last decade, a new approach for cartilage repair was suggested, and it consists in the use of engineered scaffolds able to support the growth of chondrocytes. However, still further research is required to develop suitable scaffolds, because the neo-generated tissue is often fibrocartilage, which is mechanically inferior and less durable than the one found in healthy articular joints [151]. Since the beginning of the investigation, a particular interest was attributed to PHA as interesting material for the recreation of a favorable environment for the growth of chondrocytes from stem cells.…”

Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

et al. 2021

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In recent years, biopolymers have been attracting the attention of researchers and specialists from different fields, including biotechnology, material science, engineering, and medicine. The reason is the possibility of combining sustainability with scientific and technological progress. This is an extremely broad research topic, and a distinction has to be made among different classes and types of biopolymers. Polyhydroxyalkanoate (PHA) is a particular family of polyesters, synthetized by microorganisms under unbalanced growth conditions, making them both bio-based and biodegradable polymers with a thermoplastic behavior. Recently, PHAs were used more intensively in biomedical applications because of their tunable mechanical properties, cytocompatibility, adhesion for cells, and controllable biodegradability. Similarly, the 3D-printing technologies show increasing potential in this particular field of application, due to their advantages in tailor-made design, rapid prototyping, and manufacturing of complex structures. In this review, first, the synthesis and the production of PHAs are described, and different production techniques of medical implants are compared. Then, an overview is given on the most recent and relevant medical applications of PHA for drug delivery, vessel stenting, and tissue engineering. A special focus is reserved for the innovations brought by the introduction of additive manufacturing in this field, as compared to the traditional techniques. All of these advances are expected to have important scientific and commercial applications in the near future.

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Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

et al. 2021

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“…As such, it was possible to fabricate interconnected structures of both fast crosslinking gelatin methacrylate and slow crosslinking collagen type I [ 165 ]. It should however be noted that concerns have been raised around cellular toxicity following exposure to Pluronic F-127 [ 10 ]. Looking at alternative materials as sacrificial inks, Norotte et al were able to fabricate hollow channels of multicellular pig smooth muscle cells using agarose fibres as a sacrificial ink [ 166 ].…”

Section: Designing Musculoskeletal Bioinksmentioning

confidence: 99%

“…In the autograft method of ACL reconstruction, tendons from other parts of the body, generally patella or hamstring, are used, which can lead to donor site morbidity and pain. Allografts have a risk of disease transmission and immune-mediated graft rejection [ 10 , 11 ]. Since they lack cellularity, they often require an extended period of revascularisation and incorporation (over a year) before a sports-active patient is allowed to return to play [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Biofabrication Strategies for Musculoskeletal Disorders: Evolution towards Clinical Applications

et al. 2021

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Biofabrication has emerged as an attractive strategy to personalise medical care and provide new treatments for common organ damage or diseases. While it has made impactful headway in e.g., skin grafting, drug testing and cancer research purposes, its application to treat musculoskeletal tissue disorders in a clinical setting remains scarce. Albeit with several in vitro breakthroughs over the past decade, standard musculoskeletal treatments are still limited to palliative care or surgical interventions with limited long-term effects and biological functionality. To better understand this lack of translation, it is important to study connections between basic science challenges and developments with translational hurdles and evolving frameworks for this fully disruptive technology that is biofabrication. This review paper thus looks closely at the processing stage of biofabrication, specifically at the bioinks suitable for musculoskeletal tissue fabrication and their trends of usage. This includes underlying composite bioink strategies to address the shortfalls of sole biomaterials. We also review recent advances made to overcome long-standing challenges in the field of biofabrication, namely bioprinting of low-viscosity bioinks, controlled delivery of growth factors, and the fabrication of spatially graded biological and structural scaffolds to help biofabricate more clinically relevant constructs. We further explore the clinical application of biofabricated musculoskeletal structures, regulatory pathways, and challenges for clinical translation, while identifying the opportunities that currently lie closest to clinical translation. In this article, we consider the next era of biofabrication and the overarching challenges that need to be addressed to reach clinical relevance.

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“…Moreover, in the tissue engineering are used systems, which allow for deposition of cells suspended in bioink, so-called bioprinting systems. There are four major bioprinting systems:  inject bioprinter, which uses an air pressure pulse generated by heating or piezoelectric pressure to deposit droplets of bioink,  microvalve bioprinting works by opening and closing a small valve to control the release of bioink from a cartridge under constant pneumatic pressure,  microextrusion bioprinter, which uses pneumatic or mechanical dispensing systems to continuous extrude of material,  laser-assisted bioprinter, which uses of laser energy to generate force transfer of droplets of bioink to the substrate [2,18,31,32]. Tissue engineering can be divided into two categories:  hard tissue engineering, which involves the regenerations of hard tissue such as bones, teeth and cartilage,  soft tissue engineering, which involves the regenerations of soft tissue such as skin, blood vessels, ligaments and tendons.…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…Several examples of the use of acellular additive manufacturing methods in soft tissue engineering can be found in the literature. However, bioprinting plays here an increasingly important role [32].…”

Section: Soft Tissue Engineeringmentioning

confidence: 99%

Additive manufacturing methods, materials and medical applications - the review

Laskowska

Mitura

Ziółkowska³

et al. 2021

Journal of Mechanical and Energy Engineering

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The aim of the additive manufacturing (AM) is a production of physical objects by adding material layer-by-layer based on virtual geometry developed in the computer system. The main criteria for the division of additive manufacturing methods are the way to apply the layer and the type of construction material. In most projects, the choice of method is a compromise between costs and properties (e.g. physical, chemical or mechanical) of the manufactured object. Currently, AM methods have found application in many areas of life, including industrial design, automotive, aerospace, architecture, jewellery, medicine and veterinary medicine, bringing many innovative and revolutionary solutions. The purpose of this article is to review of the additive production methods and present the potential of medical application.

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3D biofabrication for soft tissue and cartilage engineering

Cited by 30 publications

References 265 publications

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

Biofabrication Strategies for Musculoskeletal Disorders: Evolution towards Clinical Applications

Additive manufacturing methods, materials and medical applications - the review

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