3D bio-printing for use as bone replacement tissues: A review of biomedical application

Farazin, Ashkan; Zhang, Chunwei; Gheisizadeh, Amirhossein; Shahbazi, Aminadel

doi:10.1016/j.bea.2023.100075

Cited by 31 publications

(11 citation statements)

References 73 publications

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“…FDM technology-based composites derived from renewable resources have gained appeal in industries such as furniture [17], construction [18], automotive [19], and biomedical [20] and various consumer applications, driven by heightened environmental consciousness and the desire for sustainable materials [21,22]. Recently, the innovation of employing natural fibers as a new sustainable material in polymers for industrial applications has increased significantly, as Khalid et al reported [23].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Self-Polymerized Polydopamine Coating on Mechanical Properties of Polylactic Acid (PLA)–Kenaf Fiber (KF) in Fused Deposition Modeling (FDM)

Hamat,

Ishak,

Salit

et al. 2023

Polymers

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This research examines the impact of self-polymerized polydopamine (PDA) coating on the mechanical properties and microstructural behavior of polylactic acid (PLA)/kenaf fiber (KF) composites in fused deposition modeling (FDM). A biodegradable FDM model of natural fiber-reinforced composite (NFRC) filaments, coated with dopamine and reinforced with 5 to 20 wt.% bast kenaf fibers, was developed for 3D printing applications. Tensile, compression, and flexural test specimens were 3D printed, and the influence of kenaf fiber content on their mechanical properties was assessed. A comprehensive characterization of the blended pellets and printed composite materials was performed, encompassing chemical, physical, and microscopic analyses. The results demonstrate that the self-polymerized polydopamine coating acted as a coupling agent, enhancing the interfacial adhesion between kenaf fibers and the PLA matrix and leading to improved mechanical properties. An increase in density and porosity was observed in the FDM specimens of the PLA–PDA–KF composites, proportional to their kenaf fiber content. The enhanced bonding between kenaf fiber particles and the PLA matrix contributed to an increase of up to 13.4% for tensile and 15.3% for flexural in the Young’s modulus of PLA–PDA–KF composites and an increase of up to 30% in compressive stress. The incorporation of polydopamine as a coupling agent in the FDM filament composite led to an improvement in tensile, compressive, and flexural stresses and strain at break, surpassing that of pure PLA, while the reinforcement provided by kenaf fibers was enhanced more by delayed crack growth, resulting in a higher strain at break. The self-polymerized polydopamine coatings exhibit remarkable mechanical properties, suggesting their potential as a sustainable material for diverse applications in FDM.

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Section: Introductionmentioning

confidence: 99%

The Effects of Self-Polymerized Polydopamine Coating on Mechanical Properties of Polylactic Acid (PLA)–Kenaf Fiber (KF) in Fused Deposition Modeling (FDM)

Hamat,

Ishak,

Salit

et al. 2023

Polymers

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“…9,10 3D-printing is a promising technique that allows a fast production with a very fine resolution of complicated and custom-made models. 11 The revolution of 3D-printing began in the 19th century, and recently it was directed towards the graft therapy of orthopedics and traumatic defects. 12,13 Many literature reports have combined the 3D-printed scaffolds with different types of infill materials such as therapeutics-loaded hydrogel matrices for tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

3D-bioimplants mimicking the structure and function of spine units for the treatment of spinal tuberculosis

et al. 2023

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“…In their study, Fei Liu et al [ 39 ] demonstrated that a diamond lattice structure with an interconnected porosity of 81–97% is good for tissue ingrowth and vascularization. In their study, Ashkan Farazin et al [ 40 ] illustrated that a diamond scaffold with a porosity of 60 to 70% demonstrated improved cell viability and bone ingrowth. Naghavi et al [ 41 ] analyzed diamond scaffolds with a pore size of 900 to 1500 µm and found that the scaffolds within 1400 µm were within the acceptable limit of cortical bone stiffness.…”

Section: Introductionmentioning

confidence: 99%

“…The diamond lattice has several benefits, including its strut orientation, which resembles that of trabecular bone [ 40 , 47 ]. Diez-Escudero et al [ 48 ] demonstrated that, among all geometries, the diamond structure has the highest interconnectivity levels and the most uniform distribution of pore sizes.…”

Section: Introductionmentioning

confidence: 99%

Polyether-Ether-Ketone (PEEK) and Its 3D-Printed Quantitate Assessment in Cranial Reconstruction

Moiduddin,

Mian,

Elseufy

et al. 2023

JFB

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Three-dimensional (3D) printing, medical imaging, and implant design have all advanced significantly in recent years, and these developments may change how modern craniomaxillofacial surgeons use patient data to create tailored treatments. Polyether-ether-ketone (PEEK) is often seen as an attractive option over metal biomaterials in medical uses, but a solid PEEK implant often leads to poor osseointegration and clinical failure. Therefore, the objective of this study is to demonstrate the quantitative assessment of a custom porous PEEK implant for cranial reconstruction and to evaluate its fitting accuracy. The research proposes an efficient process for designing, fabricating, simulating, and inspecting a customized porous PEEK implant. In this study, a CT scan is utilized in conjunction with a mirrored reconstruction technique to produce a skull implant. In order to foster cell proliferation, the implant is modified into a porous structure. The implant’s strength and stability are examined using finite element analysis. Fused filament fabrication (FFF) is utilized to fabricate the porous PEEK implants, and 3D scanning is used to test its fitting accuracy. The results of the biomechanical analysis indicate that the highest stress observed was approximately 61.92 MPa, which is comparatively low when compared with the yield strength and tensile strength of the material. The implant fitting analysis demonstrates that the implant’s variance from the normal skull is less than 0.4436 mm, which is rather low given the delicate anatomy of the area. The results of the study demonstrate the implant’s endurance while also increasing the patient’s cosmetic value.

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3D bio-printing for use as bone replacement tissues: A review of biomedical application

Cited by 31 publications

References 73 publications

The Effects of Self-Polymerized Polydopamine Coating on Mechanical Properties of Polylactic Acid (PLA)–Kenaf Fiber (KF) in Fused Deposition Modeling (FDM)

The Effects of Self-Polymerized Polydopamine Coating on Mechanical Properties of Polylactic Acid (PLA)–Kenaf Fiber (KF) in Fused Deposition Modeling (FDM)

3D-bioimplants mimicking the structure and function of spine units for the treatment of spinal tuberculosis

Polyether-Ether-Ketone (PEEK) and Its 3D-Printed Quantitate Assessment in Cranial Reconstruction

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