3D arterial spin tagging studies of cognitive activation

Ye, F.Q.; Ellmore, TM; Berman, Karen F.; Holt, John L.; Lawrence, KS St.; Duyn, J.H.; Frank, J. A.; Weinberger, D.R.; McLaughlin, Anne Collins

doi:10.1016/s1053-8119(00)91413-7

Cited by 4 publications

(4 citation statements)

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“…Some factors cannot be controlled and should be optimized, depending on the specifi c clinical question. For example, Ye et al ( 51 ) observed levels of correlation between PET and ASL data that depended on the tissue classes. ASL was highly accurate for studying gray matter but not white matter.…”

Section: Discussionmentioning

confidence: 99%

Resting-State Perfusion in Nonmedicated Schizophrenic Patients: A Continuous Arterial Spin-labeling 3.0-T MR Study

Scheef

Manka²,

Daamen³

et al. 2010

Radiology

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CASL in schizophrenia revealed patterns of hypo- and hyperperfusion similar to the perfusion patterns in previously published positron emission tomographic and single photon emission computed tomographic studies. The advantages of CASL, including independence from injected contrast agents, no irradiation, and fast acquisition time, may facilitate intensive perfusion studies of the early recognition of schizophrenia and other psychiatric disorders, as well as longitudinal disease-monitoring research of these conditions.

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Section: Discussionmentioning

confidence: 99%

Resting-State Perfusion in Nonmedicated Schizophrenic Patients: A Continuous Arterial Spin-labeling 3.0-T MR Study

Scheef

Manka²,

Daamen³

et al. 2010

Radiology

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“…Versions of the technique have been validated in animals with microspheres 49 and in the normal human brain with H 2 O 15 PET. 50 Initial clinical explorations of the technique have been performed in cerebrovascular disease, [51][52][53] epilepsy, 54 and dementia. 55 Recent reports of echoplanar ASL techniques applied to brain tumors have shown increased perfusion in pretreatment glioma 56 and correlated response of brain metastases to radiation therapy and ASL perfusion.…”

Section: Wong and Bremmentioning

confidence: 99%

Antiangiogenesis Treatment for Glioblastoma Multiforme: Challenges and Opportunities

Wong¹,

Brem²

2008

J Natl Compr Canc Netw

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Angiogenesis is a major hallmark of cancer cells, and glioblastomas are among the most angiogenic tumors. The cascade of angiogenesis is probably initiated by hypoxia, leading to the production of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Both VEGF and bFGF have paracrine effects on endothelial cells, pericytes, or both, causing the formation of hyperpermeable tumor blood vessels. Advanced MRI techniques, such as dynamic contrast-enhanced, dynamic susceptibility, and arterial spin labeling MRI, have provided semiquantitative measurements of tumor vascular permeability and perfusion. A decrease in vascular permeability and perfusion can be detected after antiangiogenesis drug treatment, either with monoclonal antibody such as bevacizumab that sequesters VEGF, or small-molecule VEGF receptor tyrosine kinase inhibitors. Therefore, antiangiogenesis therapies are being increasingly adopted for treating glioblastomas. However, caution must be exercised because neural stem cells are also sensitive to antiangiogenesis drugs and the combined effect of ionizing radiation. This article summarizes 30 years of laboratory and clinical research on glioblastoma angiogenesis and discusses its underlying biology, clinical trial results, vascular neuroimaging, and the potential side effects of antiangiogenesis treatment.

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“…In the present study, steady-state CBV measurements from pre-and post-CA T1 measurements (for the Bookend approach) as well as from the VASO method were used to calibrate CBF from DSC-MRI in a test-retest study in 20 healthy subjects, and the results were compared to CBF from pseudo-continuous arterial spin labeling (pCASL). Absolute CBF values from pCASL have previously shown reasonable agreement with reference methods such as PET [11,12], and a comparison between pCASL and calibrated DSC-MRI is thus of relevance. The VASO-and Bookend-calibrated CBF estimates were also mutually compared and the repeatability of the measurements was investigated.…”

Section: Introductionmentioning

confidence: 74%

Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL

Lindgren

Wirestam

Bloch

et al. 2014

Magn Reson Mater Phy

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General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractObjective: Dynamic susceptibility-contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level of DSC-MRI CBF. Materials and Methods:Twenty healthy volunteers were scanned in a test-retest approach. Independent CBV measurements, for calibration, were accomplished using a T1-based contrast agent steady-state method (referred to as Bookend) as well as a blood-nulling vascular space occupancy (VASO) approach. Calibrated DSC-MRI was compared with pseudo-continuous arterial spin labeling (pCASL).Results: For segmented grey matter (GM) regions of interests (ROIs), pCASL-based CBF was 63±11 ml/(min100g) (mean±SD). Nominal CBF from non-calibrated DSC-MRI was 277±61 ml/(min100g), while calibrations resulted in 56±23 ml/(min100g) (Bookend) and 52±16 ml/(min100g) (VASO). Calibration tended to eliminate the overestimation, although the repeatability was, generally, moderate and the correlation between calibrated DSC-MRI and pCASL was low (r<0.25). However, using GM instead of WM ROIs for extraction of CFs resulted in improved repeatability. Conclusion:Both calibration approaches provided reasonable absolute levels of GM CBF, although the calibration methods suffered from low signal-to-noise ratio, resulting in weak repeatability and difficulties in showing high degrees of correlation with pCASL measurements.3

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3D arterial spin tagging studies of cognitive activation

Cited by 4 publications

References 0 publications

Resting-State Perfusion in Nonmedicated Schizophrenic Patients: A Continuous Arterial Spin-labeling 3.0-T MR Study

Resting-State Perfusion in Nonmedicated Schizophrenic Patients: A Continuous Arterial Spin-labeling 3.0-T MR Study

Antiangiogenesis Treatment for Glioblastoma Multiforme: Challenges and Opportunities

Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL

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