3D amplified single-cell RNA and protein imaging identifies oncogenic transcript subtypes in B cell acute lymphoblastic leukemia
Sungyoung Choi,
Suyeon Shin,
Yoon-Jin Kim
et al.
Abstract:Simultaneous in situ detection of transcript and protein markers at single-cell level is essential for gaining a better understanding of tumor heterogeneity and for predicting and monitoring treatment responses. However, the limited accessibility to advanced 3D imaging techniques has hindered its rapid implementation. Here, we present a 3D single-cell imaging technique, termed 3D digital rolling circle amplification (4DRCA), capable of the multiplexed and amplified simultaneous digital quantification of single… Show more
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