Purpose: To automatically segment the skull from the MRI data using a model-based three-dimensional segmentation scheme.
Materials and Methods:This study exploited the statistical anatomy extracted from the CT data of a group of subjects by means of constructing an active shape model of the skull surfaces. To construct a reliable shape model, a novel approach was proposed to optimize the automatic landmarking on the coupled surfaces (i.e., the skull vault) by minimizing the description length that incorporated local thickness information. This model was then used to locate the skull shape in MRI of a different group of patients.
Results:Compared with performing landmarking separately on the coupled surfaces, the proposed landmarking method constructed models that had better generalization ability and specificity. The segmentation accuracies were measured by the Dice coefficient and the set difference, and compared with the method based on mathematical morphology operations.
Conclusion:The proposed approach using the active shape model based on the statistical skull anatomy presented in the head CT data contributes to more reliable segmentation of the skull from MRI data. BECAUSE OF THE weak signal of bony structures in MRI and the high complexity of the skull topology, automatic segmentation of the skull with good reliability in MRI still remains a challenging problem. Whereas the segmentation of skull in MRI is crucial in research related to analyzing the skull morphology, such as the construction of realistic models of the head (1) and the quantification of bone growth abnormality (2). In such tasks, the motivation of using the MRI instead of computed tomography (CT) is to protect subjects from ionizing radiation and to acquire clear imaging of soft tissues at the same time for multiple analysis purposes.Being able to characterize shapes with natural variability, the active shape model (ASM) introduced by Cootes et al (3) found a variety of applications in medical image segmentation and analysis. Typically, when applied to medical image segmentation problems, the active shape model is built from a group of training shapes, which share the same modality as the images to be segmented (4). To define skull boundaries in MRI, the CT data are worthwhile to be referred to for anatomical information. The first reason is that the active shape model is unlikely to be acquired from the MRI data per se, as automatic segmentation of skull in MRI is the main problem to be solved while annotating the skull landmarks manually to establish the training set is infeasible. Second, brain atlases with skull information only represent the anatomy of a single subject, which is not statistically meaningful. Third, the bony structures are very clear in the CT data, and they can be easily segmented using simple thresholding.Thresholding and region growing are often applied to segment scalps, skulls, and brains (5). Dogdas et al (6) used a combination of thresholding and mathematical morphological operations to find the boundaries of sc...