3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

“…The growing demand for computational models in clinical applications requires the development of increasingly detailed mathematical models and efficient numerical methods [21][22][23][24][25][26][27][28][29][30]. In the context of cardiac electromechanics, a biophysically detailed model of the human heart encompasses all the multiscale and multiphysics processes underlying the cardiac function, ranging from the cellular (microscale) to the organ (macroscale) level, such as the propagation of the electrical signal, the active and passive mechanics, and the interaction with the circulatory system [22].…”

An accurate, robust, and efficient finite element framework with applications to anisotropic, nearly and fully incompressible elasticity

“…All computational models of cardiac EM presented in the literature so far, e.g., [ 28 , 71 , 95 , 110 – 116 ], are missing one or mostly more of the above points. While the importance of model components (i)–(v) was discussed extensively in references above we could show in this paper that also (vi) is necessary to compute accurate stress fields in the tissue.…”

An integrated multiscale CFD model of the human heart

“…To prescribe a physiological displacement to the domain boundary, we employ the ventricular electromechanics (EM) model developed in Regazzoni et al (2022); Piersanti et al (2022) coupled to the surrounding circulation described by a 0D lumped-parameter hemodynamic model. We introduce a novel procedure that combines an 2022)).…”