3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells

Lei, Kecheng; Tan, Shaoying; Du, Wenpei; Lin, Shengchao; Zheng, Yang; Zou, Fangyuan; Xu, Yufang; Liu, Jianwen

doi:10.1007/s13277-015-3231-7

Cited by 11 publications

(9 citation statements)

References 51 publications

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“…JAK/STAT signal transduction pathway can promote the expression of many downstream growth factors [such as vascular endothelial growth factor A (VEGFA), insulin-like growth factor-1 and matrix metalloproteinase], and can activate, as well as promote, angiogenesis at the tumor site, thus promoting cell proliferation and survival and inhibiting apoptosis (10–12). In addition, JAK/STAT signal transduction pathway also plays regulatory roles in glycolysis, inflammatory response and epithelial mesenchymal transformation (13,14). However, the regulation processes of apoptosis, glycolysis, inflammatory response, epithelial mesenchymal transformation and angiogenesis, by the JAK/STAT signal transduction pathway are accompanied by tumor cell metastasis.…”

Section: Discussionmentioning

confidence: 99%

Association analyses of the JAK/STAT signaling pathway with the progression and prognosis of colon cancer

et al. 2018

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The present study investigated the association between the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway with tumor progression and prognosis of colon cancer. A total of 62 patients with colon cancer were selected as the colon cancer group, and 40 patients with colon lesions were selected as the benign colon lesion group. Immunohistochemistry was used to detect the expression levels of JAK-1 and STAT-3 proteins in colon tissues. The association of JAK-1 and STAT-3 proteins with the pathological parameters and prognosis of colon cancer were analyzed. The total positive rates of JAK-1 and STAT-3 proteins in lesions of patients in the colon cancer group were significantly higher compared with those in the benign colon lesion group (P<0.05). The positive expression of JAK-1 and STAT-3 proteins in patients with colon cancer were not significantly associated with sex, age, tumor differentiation degree and neurovascular invasion (P>0.05), but significantly associated with the clinical stage of colon cancer, tumor infiltration depth and lymph node metastasis (P<0.05). The survival time of patients with colon cancer with positively-expressed JAK-1 and STAT-3 proteins was significantly shorter compared with that of patients with negatively-expressed JAK-1 and STAT-3 proteins (P<0.05). tumor-node-metastasis (TNM) stage, lymph node metastasis and the expression of JAK-1 and STAT-3 proteins in the tumor were associated with the prognosis of patients with colon cancer (P<0.05). TNM stage and the expression levels of JAK-1 and STAT-3 proteins were independent risk factors influencing the prognosis of colon cancer (P<0.05). The JAK/STAT signal may be used as a novel tumor marker and prognostic factor for the diagnosis, assessment and prognosis of colon cancer.

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Section: Discussionmentioning

confidence: 99%

Association analyses of the JAK/STAT signaling pathway with the progression and prognosis of colon cancer

et al. 2018

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“…Reverse transcription was performed with ReverTra Ace qPCR RT Kit (Toyobo, Japan), and primers were designed and purchased from Sangon Biotech. Real-time PCR was performed with tests were performed in triplicate [27].…”

Section: Validation Of the Expression In Degs In Q-pcrmentioning

confidence: 99%

Immune-associated biomarkers for early diagnosis of Parkinson’s disease based on hematological lncRNA–mRNA co-expression

Lei

Zhang²,

et al. 2020

Bioscience Reports

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Early stage diagnosis of Parkinson's disease (PD) is challenging without significant motor symptoms. The identification of effective molecular biomarkers as a hematological indication of PD may help improve the diagnostic timeliness and accuracy. In this paper, we analyzed and compared the blood samples of PD and control (CTR) patients to identify the disease-related changes and determine the putative biomarkers for PD diagnosis. Based on the RNA sequencing analysis, differentially expressed genes (DEGs) were identified, and the co-expression network of DEGs was constructed using the weighted correlation network analysis (WGCNA). The analysis leads to the identification of 87 genes that were exclusively regulated in the PD group, whereas 66 genes were significantly increased and 21 genes were significantly decreased in contrast to the control group. The results indicate that the core lncRNA-mRNA co-expression network greatly changes the immune response in PD patients. Specifically, the results showed that PWAR6, LINC00861, AC83843.1, IRF family, IFIT family and CaMK4 may play important roles in the immune system of PD. Based on the findings from this the present study, future research aims at identify novel therapeutic strategies for PD.

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“…Sensitivity to ROSinduced oxidative stress vary from one cancer cell to another (21,22). Therefore, elevated ROS levels stimulated by anticancer drugs leads to the induction of apoptosis in the cell (11). It has been reported that ROS promote degradation of CAV-1 via the proteasome system which in turn enhances the proliferation and migration of lung cancer cells (12).…”

Section: Discussionmentioning

confidence: 99%

“…An understanding of their interaction may offer a novel strategy for treatment of ESCC and improvement of clinical outcomes. The accumulation of ROS regulates the proliferation and apoptosis of tumor cells (11). Caveolin-1 (CAV-1) promotes the proliferation and migration of lung cancer cells via a mechanism involving the PI3K/Akt pathway.…”

Section: Introductionmentioning

confidence: 99%

TBRG4 silencing promotes progression of squamous cell carcinoma via regulation of CAV-1 expression and ROS formation

Wang

Luo

Liu

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Esophageal cancer is the eighth most common cancer globally. Transforming growth factor β regulator 4 (TBRG4) and caveolin-1 (CAV-1) are implicated in tumor progression. The aim of this study was to investigate the expressions of TBRG4 and CAV-1 in esophageal squamous cell carcinoma (ESCC), and their relationship with reactive oxygen species (ROS) formation. Human ESCC cell lines (EC9706, TE-1, and Eca109), and normal esophageal mucosal cell line (Het-1) were used in this study. The silencing of TBRG4 and/or CAV-1 by sh-RNA or overexpression of CAV-1 after TBRG4 knockdown was used to assess ROS levels. The results showed that down-regulation of TBRG4 reduced CAV-1 expression, and promoted ROS formation in ESCCs (p < 0.01). However, CAV-1 overexpression increased the expression level of TBRG4, but decreased ROS level in EC9706 cells (p < 0.01). Similarly, TBRG4 knockdown significantly reduced CAV-1 expression, promoted ROS formation, and caused cell cycle arrest at G0/G1 phase (p < 0.01). Caveolin-1 (CAV-1) knockdown also promoted cell apoptosis, cellular ROS formation and cell cycle arrest at G0/G1 phase (p < 0.01). However, CAV-1 overexpression in sh-TBRG4-treated EC9706 cells significantly upregulated TBRG4 expression, but significantly reduced the level of ROS, and inhibited cell-cycle arrest and apoptosis (p < 0.01). The enhancements in bcl-2/ bax ratio, cytochrome c expression, and ROS levels by sh-TBRG4 were significantly reversed by CAV-1 overexpression in EC9706 cells. These results show that the upregulated expression of TBRG4 or CAV-1 promotes ESCC progression via regulation of intracellular ROS levels and inhibition of mitochondria-dependent apoptotic pathway.

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3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells

Cited by 11 publications

References 51 publications

Association analyses of the JAK/STAT signaling pathway with the progression and prognosis of colon cancer

Association analyses of the JAK/STAT signaling pathway with the progression and prognosis of colon cancer

Immune-associated biomarkers for early diagnosis of Parkinson’s disease based on hematological lncRNA–mRNA co-expression

TBRG4 silencing promotes progression of squamous cell carcinoma via regulation of CAV-1 expression and ROS formation

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