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Design and Synthesis of Long‐Wavelength Fluorescent Boronic Acid Reporter Compounds

“…However, most of these compounds are very hydrophobic and cannot be used in aqueous solutions. Heagy and co-workers [55,56] synthesized a series of N-phenylboronic acid derivatives of 1,8-naphthalimide, some of which can be used in phosphate buffer at pH 7.4. Among these compounds, 3-nitro-N-phenylnaphthalimidylboronic acid [57] emits at 550 nm and is water-soluble.…”

A new boronic acid fluorescent sensor based on fluorene for monosaccharides at physiological pH

“…The pH of the solution was controlled using minimum amount of sodium hydroxide and hydrochloric acid solutions. Titration curves against pH were measured in buffer solutions: acetate buffer for pH 2.5-5.5, phosphate buffer for pH 6.0-9.0, and carbonate buffer for pH 10-12 [38,39].…”

“…where I min and I max are the initial (no sugar) and final fluorescence intensities at 387 nm [39,[41][42][43]. …”

Resonance Energy Transfer Nanobiosensors Based on Affinity Binding between Apo-Enzyme and Its Substrate

“…25 Taking this value and the experimentally determined change in energy transfer efficiency, eq 1 was used to compute the change in the average distance (R) between FITCdextran and TAG as ~11 Å with the addition of 90 mM glucose. (1) where E is the energy transfer efficiency and F da and F d represent the donor fluorescence intensities with and without the addition of acceptor, respectively.…”

“…1 Frequent monitoring of glucose levels, followed by appropriate actions to maintain normoglycemia, is necessary to minimize the adverse affects of diabetes. A noninvasive glucose sensor, the so-called "holy grail" of medical devices, would help improve the lives of many people by reducing the pain associated with the testing, thus improving the quality of the treatment.…”