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Towler, Mark R.; Crowley, Clare M.; Murphy, Dorothy M.; O'Callaghan, A. M. C.

doi:10.1023/a:1016570819402

Cited by 22 publications

(5 citation statements)

References 13 publications

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“…Bioactive silicate glasses are clinically used as bone grafts [1] and are also of interest for use as implant coatings [2], in aluminiumfree glass polyalkenoate (ionomer) bone cements [3] and even in dentifrices [4], and in all these applications addition of fluoride would be beneficial. Fluoride is well known to prevent dental cavities by inhibiting enamel and dentine demineralisation, enhancement of remineralisation and inhibition of bacterial enzymes [5,6].…”

Section: Introductionmentioning

confidence: 99%

Fluoride-containing bioactive glass-ceramics

Brauer

Anjum

Mneimne

et al. 2012

Journal of Non-Crystalline Solids

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Section: Introductionmentioning

confidence: 99%

Fluoride-containing bioactive glass-ceramics

Brauer

Anjum

Mneimne

et al. 2012

Journal of Non-Crystalline Solids

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“…Strontium promotes the replication of pre-osteoblastic cells [107] and stimulates bone formation [108]. Zinc plays a role in the mechanical integrity of the cement [109] as well as serving a physiological role. Zinc is an essential element for the growth and normal development of humans [110] and is required for DNA synthesis, cell division and protein synthesis [110].…”

Section: Promise Of Gpcs For Orthopedic Applicationsmentioning

confidence: 99%

Development of Novel Adhesives for Sternal and Radial Fixation

Mehrvar

2024

Preprint

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Wrist fractures can be difficult to treat due to advanced age of the patient, medical co-morbidities, and comminution of bone. In addition, cerclage wires remain the current standard of care following median sternotomy, despite significant complications including dehiscence and infection. Glass polyalkenoate cements (GPCs) have been widely used in dentistry and ear, nose, and throat (ENT) applications but have yet to be indicated for orthopaedic applications. This dissertation focuses on the development of novel GPCs to improve on current treatments for distal radial fixation and sternal fixation. Two injectable GPCs, derived from either glass A (mole fraction: SiO2:0.48, ZnO:0.36, CaO0.12, SrO: 0.04), Glass B (mole fraction: SiO2:0.48, ZnO:0.355, CaO:0.06, SrO:0.08, P2O5:0.02, Ta2O5:0.005), or Glass C (mole fraction: SiO2:0.48, ZnO:0.351, CaO:0.073, SrO:0.143, P2O5:0.027) were investigated using both sternal and radial cadaveric models. Radii fixated with a GPC were ~60% as strong as their intact biological pair when tested to failure. Radii fixated with a GPC were found to be significantly stiffer than their biological pairs fixated with a volar locking plate when tested under fatigue. Further, midline sternal displacement for adhesive-enhanced sternal closures were significantly less than standard wire cerclage. Novel GPCs were investigated in a sheep model by filling a non-critical defect. The GPCs were derived from either Glass A or Glass B at a particle size of <45 m, with a cement formulation consisting of [10g glass : 4g (poly)acrylic acid : 6ml water : 0.75g Trisodium Citrate]. The GPCs demonstrated significant bone resorption surrounding the material and were deemed non-viable in-vivo formulations. The cause of the resorption was believed to be the persistent inflammatory reaction surrounding numerous degraded GPC fragments given that debris release has been observed to cause bone resorption in studies related to polyethylene biomaterials. As a result, the GPC formulation derived from Glass A was improved by increasing the PAA molecular weight from 50k to 210k Mw, increasing the glass particle size from 20-45 m to 45-63 m and reducing the P:L ratio from 1:1 to 1:0.6. The improved GPC (GPC+) was investigated in a rabbit model, followed by a sheep model, by filling a non-critical defect. MicroCT images from all three GPC+ samples in the rabbit model did not show any bone resorption, while histology slides showed normal bone turnover. In the sheep model, five of seven GPC+ samples were associated with mild bone resorption, occurring because of increased osteoclast activity. However, two samples in sheep exhibited no resorption and appeared to stimulate increased bone density at the implant site. The in-vivo response with regards to GPC+ was more favorable than in the previous in-vivo trial. To the best knowledge of the candidate, this dissertation is the first to report a GPC formulated using a glass particle size of 45–63 m, a GPC investigated for sternal and distal radial fixation using a cadaveric model, as well as the biocompatibility of a GPC using a sheep model.

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“…The chemistry of the glass composition significantly affects the properties of the resultant cement composition [16]. The reactivity of the glass phase depends on the structure of the glass, the number of modifying cations, their valency and then on their acidity/basicity [17].…”

Section: Introductionmentioning

confidence: 99%

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

2019

Preprint

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In this work, we investigated the effects of strontium incorporation in the glass phase of glass ionomer cements (GIC). Three different glass compositions were synthesized with 0, 5, and 10 mol% of SrO addition. GICs were prepared by the addition of 50 wt% polyacrylic acid (PAA) at powder to liquid ratio of 1:1.5. Initial characterization on the cement series was to study their rheological behavior. Cements represented working times between 50-64 seconds and setting times of 356-452 seconds. Rheological results indicated that the addition of strontium decreases the working and setting times of the cements. To analyze the mechanical properties, compressive and flexural strength studies were performed after 1, 10, and 30 days incubation in simulated body fluid. The compressive strength of the cements increased as a function of incubation time, with the strontium containing compositions showing the highest strength at 34 MPa and after 30 days of incubation. Biaxial flexural strength of the cements was not significantly affected by the composition and maturation time and ranged between 13.4 to 16.3 MPa. In-vitro bioactivity of the cements was analyzed using SBF trials and after 1, 10, and 30 days incubation periods.Strontium containing cements, showed higher solubility with higher amounts of calcium phosphate surface depositions only after 10 days incubation. The elemental identifications of the surface depositions indicated high amounts of Ca, P and Zn are present on the surface of SBF incubated samples.

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Cited by 22 publications

References 13 publications

Fluoride-containing bioactive glass-ceramics

Fluoride-containing bioactive glass-ceramics

Development of Novel Adhesives for Sternal and Radial Fixation

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

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