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Новикова, Е. В.; Tishchenko, E. V.; Иозеп, А. А.; Passet, B. V.

doi:10.1023/a:1020357301364

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…The exact structure of the oxidized polysaccharides is still controversially discussed in the literature. − So far, structural motifs have not been systematically discussed based on clear spectroscopic evidence. Some studies have concluded that aldehyde groups along the polymer chain must be easily attacked in a random way by the nearest neighboring hydroxyl groups, leading to a variety of different stabilized products.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Periodate-Oxidized Polysaccharides: Dialdehyde Xylan (DAX)

et al. 2016

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The cleavage of the C2-C3 bond in the building units of 1 → 4-linked polysaccharides by periodate formally results in two aldehyde units, which are present in several masked forms. The structural elucidation of such polysaccharide dialdehydes remains a big challenge. Since polysaccharide derivatives are increasingly applied in materials technology, unveiling the exact structure is of utmost importance. To address this issue for xylan, dialdehyde xylan (DAX, oxidation degree of 91.5%) has been synthesized as water-soluble polymer. The ATR-FTIR spectrum of DAX showed free aldehyde to be absent and exhibited a characteristic absorption at 858 cm(-1) related to hemiacetal groups. By a combination of 1D and 2D NMR techniques, it was confirmed that oxidized xylan is present as poly(2,6-dihydroxy-3-methoxy-5-methyl-3,5-diyl-1,4-dioxane). Based on GPC analysis, the DAX polymer shows a slightly lower molar mass (6.6 kDa) compared to the starting material (7.7 kDa) right after oxidation, and degraded further after one month of storage in 0.1 M NaCl solution (4.3 kDa). The oxidized xylan demonstrated lower thermal stability upon TGA analysis and a greater amount of residual char (20.6%) compared to the unmodified xylan (13.7%).

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Periodate-Oxidized Polysaccharides: Dialdehyde Xylan (DAX)

et al. 2016

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“…And it is well known that the degradation rate of oxidized dextran becomes higher as pH increases. 29,30 Considering the alkaline degradation of oxidized dextran, 0.1 M pH 5.0 acetate buffer was chosen as reaction medium. We investigated the performance of AD coating by controlling the extent of oxidation and varying the concentration of AD.…”

Section: Optimization Of Ad Coating On Amino Beadsmentioning

confidence: 99%

Dextran-silane coating chemistry for SiO2-based suspension array system

Cao

Duan

et al. 2011

Polym. Chem.

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“…Dextran was coupled to the aminated polyurethane surface according to well-established procedures, 12,[26][27][28] specifically that described by Dai et al 15 in which dextran is partially activated by periodate. Briefly, a 65 mM solution of NaIO 4 in water was added to 2.3 mM dextran solution in 0.2 M Na 2 HPO 4 , pH 7.5, to achieve a molar ratio relative to dextran glucose monomer of 0.5.…”

Section: Dextran Coupling To Aminated Polyurethanementioning

confidence: 99%

Surface functionalization of polyurethane for the immobilization of bioactive moieties on tissue scaffolds

2008

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Segmented polyurethanes are widely used in medical devices because of their desirable physical and chemical properties and proven biocompatibility. While polyurethane is in many respects an ideal tissue scaffold, its performance is no better than other synthetic polymers, which is due in part to its surface properties. Here, we describe a method for the functionalization of polyurethane scaffolds that involves physically incorporating another polymer (poly(ethyleneimine)) such that the surface integrity and bulk properties are retained; the primary amine groups thus incorporated into the polyurethane surface enable subsequent coupling with dextran and recombinant peptides by means of reductive amination. The efficacy of the surface functionalization of a medical grade aliphatic poly(ether)urethane is verified by surface analysis (secondary ion mass spectrometry) and fluorescence and spectrophotometric assays adapted specifically for this purpose. Further assessment of the surfaces by direct cell contact and analysis of the cellular response in terms of cell coverage and morphology before and after modification with the specific peptide sequences GRGDSPK and recombinant Fibrillin-1 fragment PF9

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Cited by 6 publications

References 2 publications

Synthesis and Characterization of Periodate-Oxidized Polysaccharides: Dialdehyde Xylan (DAX)

Synthesis and Characterization of Periodate-Oxidized Polysaccharides: Dialdehyde Xylan (DAX)

Dextran-silane coating chemistry for SiO2-based suspension array system

Surface functionalization of polyurethane for the immobilization of bioactive moieties on tissue scaffolds

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