2000
DOI: 10.1023/a:1009616228304
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Abstract: Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

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Cited by 2,448 publications
(961 citation statements)
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References 47 publications
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“…Many scientific literatures have reported that oxidative stress certainly can induce apoptosis in cells (Simon, Haj‐Yehia, & Levi‐Schaffer, 2000). Upon initiating apoptosis, cytochrome C is released from mitochondria and triggers cleavage of caspases (Bergmann, Yang, & Srivastava, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…Many scientific literatures have reported that oxidative stress certainly can induce apoptosis in cells (Simon, Haj‐Yehia, & Levi‐Schaffer, 2000). Upon initiating apoptosis, cytochrome C is released from mitochondria and triggers cleavage of caspases (Bergmann, Yang, & Srivastava, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…ROS also have been known to induce apoptosis of cells (Simon, Haj-Yehia, & Levi-Schaffer, 2000). Recently, a review article appeared in print thoroughly discussed the role of egg yolk carotenoids as an antioxidants exerting protective effects against oxidative damage .…”
Section: Cvds Oxidative Stress Alzheimer's and Cancermentioning
confidence: 99%
“…24 As Rac1 is a well known component of the NADPH oxydase complex that produces reactive oxygen species (ROS) once activated, 25 reduction of Rac1 activities might also reduce ROS production and favor cell survival. 26 Figure 2. Focused Principal Component Analysis (fPCA) of RhoA, Rac1, Cdc42 activities and expression levels of FARP1, ARHGEF1 and ARHGAP36 in pheochromocytoma.…”
Section: Down-regulation Of Rho Gtpases and Tumorigenesismentioning
confidence: 99%