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Abstract

The experiments reported here show that animals with different levels of acquisition of a conditioned passive avoidance reflex retrieved the reflex differently on systematic testing over a period of 28 days. Animals with the highest and high levels of training reproduced the reflex stably. Animals with an intermediate level of training reproduced the reflex with significant variation. Convulsions induced by pentylenetetrazole (75 and 50 mg/kg. i.p.) resulted in amnesia. The amnestic effect of pentylenetetrazole convulsions depended on the ratio of the intensity of training and the intensity of the induction of convulsions. Reminding, provided by presentation of an unconditioned stimulus, removed the amnestic effect of the convulsive state. Training led to significant decreases in the parameters determining the severity of the convulsive state. The convulsive state was a dissociative state, as subconvulsive doses of pentylenetetrazole (30 mg/kg, i.p.) removed the amnestic effect of convulsive doses. The dissociated state was reproduced by pharmacological reminding of the state of anxiety and fear which was formed during training. A subcataleptic dose of haloperidol (0.25 mg/kg, i.p.) induced a state of fear and removed the amnestic effect of the convulsive state. The same dose of haloperidol improved retrieval of the reflex in animals with low levels of training, i.e., those in which retrieval hardly occurred in normal conditions.

Neurochemical and Behavioral Features in Genetic Absence Epilepsy and in Acutely Induced Absence Seizures

“…It has been shown [440] that the induction of LTD by low frequency stimulation in hippocampal CA 1 neurons is under the influence of both NMDA and GABA receptors; both D 1 and D 2 receptors are involved in the modulation of LTD (activation of D 1 receptors enhances LTD, activation of D 2 receptors inhibits it) and the induction of LTD is blocked by picrotoxin, this effect is superseded by D 1 receptors agonist SKF-38393. Our results [441] also point to synergistic interactions of GABA A and DA receptors in memory retrieval.…”

Types of bioinformatic programs in the continuum of regulatory peptides and non-peptide mediators. Traits of interaction of dopamine and serotonin systems

“…Bazyan et al [76] analyzed some parameters of the activities of the 5 HT and DA systems in the brain of animals with emotionally negative and positive states, which were revealed with the use of emotional reso [75] nance (the performance of the avoidance response by one animal after the perception of signals of the pain ful stimulation of another animal). The authors believe that emotionally negative states are formed by enhancement of the activity of 5 HT system and a decrease in the activity of the DA(NE) system of the brain.…”