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Cho, Sung‐Yeon; Park, Sang-Joon; Kwon, Myung-Ja; Jeong, Tae‐Sook; Bok, Song Hae; Choi, Woo-Young; Jeong, Won–Il; Ryu, Si-Yun; Hee, Sun; Lee, Cha-Soo; Song, Jae-Chan; Jeong, Kyu‐Shik

doi:10.1023/a:1021624520740

Cited by 279 publications

(80 citation statements)

References 34 publications

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“…NF-kB, a nuclear transcription factor, is a regulator of inflammatory processes (Jeong et al, 2014). Previous studies demonstrated that treatment with quercetin inhibits LPS-induced NF-kB activation in RAW 264.7 macrophages (Cho et al, 2003). In the present study, LPS greatly increased NF-kB concentrations in human PBMCs compared with the normal control group.…”

Section: Discussionsupporting

confidence: 54%

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

Zhang

Lin

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Quercetin, a dietary flavonoid abundant in fruits, vegetables, and herbs, presents various pharmacological effects. This study aimed to investigate the anti-inflammatory effect and the underlying mechanism of quercetin in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs). Cell viability was measured by the Cell Counting Kit-8 assay. The mRNA expression of Toll-like receptor 2 (TLR2) was assessed by quantitative real-time polymerase chain reaction. Inflammatory cytokine secretions and nuclear factor (NF)-kB levels were analyzed by enzyme-linked immunosorbent assay. Our findings showed that quercetin significantly reduced LPS-induced cytotoxicity in human PBMCs. Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs. Moreover, quercetin reduced the LPS-induced increase in the expression of TLR2 mRNA and decreased the NF-kB concentration in LPS-stimulated human PBMCs. The data indicates that quercetin plays an important role in

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Section: Discussionsupporting

confidence: 54%

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

Zhang

Lin

et al. 2016

Genet. Mol. Res.

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“…Recent investigations suggest that tyrosine kinase and MAP kinase pathway might be potential pharmacological targets. 8 Flavonoids are low molecular weight compounds rich in seeds, citrus fruits, red wine, tea, and olive oil. Flavonoids exert several biological activities, which are mainly related to their ability to inhibit enzymes and/or to their antioxidant properties, and are able to regulate the immune response.…”

Section: Introductionmentioning

confidence: 99%

Effect of Quercetin in the UV-Irradiated Human Keratinocyte HaCaT Cells and A Model of Its Binding To p38 MAPK

Jnawali¹,

Lee²,

Shin³

et al. 2014

Bulletin of the Korean Chemical Society

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Quercetin is a major dietary flavonoid found in onions, apples, tea, and red wine, and potentially has beneficial effects on disease prevention. We carried out this study to investigate the effect of quercetin on UVB-induced matrix metalloproteinase-1 (MMP-1) expression in human keratinocyte HaCaT cells and to further understand the mechanisms of its action. The anti-inflammatory activity of quercetin was investigated and quercetin significantly suppressed the NO production in LPS-stimulated RAW264.7 mouse macrophages. Post treatment of quercetin decreased UV irradiation-induced phosphorylation of JNK, p38 MAPK, and ERK by 91%, 21%, and 17%, respectively. MMP-1 is mainly responsible for the degradation of dermal collagen during the aging process of human skin and quercetin suppressed the UVB-induced MMP-1 by 94%. Binding studies revealed that quercetin binds to p38 with high binding affinity (1.85 × 10 6 M −1). The binding model showed that the 4′-hydroxy groups of the B-ring of quercetin participated in hydrogen bonding interactions with the side chains of Lys53, Glu71, and Asp168 and the 5-hydroxy group of the A-ring formed a hydrogen bond with the backbone amide of Met109. The major finding of this study shows that quercetin inhibits phosphorylation of JNK, p38 MAPK, and ERK pathway leading to the prevention of MMP-1 expression in human keratinocyte HaCaT cells. Therefore, our findings suggested the potentials of quercetin as a skin anti-photoaging agent.

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“…Regarding the flavonoids in the extract, quercetin is the predominant flavonoid found. A previous study reported that pretreatment with quercetin significantly inhibited NO production, and iNOS, TNF-, IL-1, and IL-6 expression in the same cell model by inhibiting phosphorylation of Erk1/2 and p-38 MAPK via stabilizing the NF-B/IB complex [19]. Recently, the antioxidant capacity of quercetin was also examined comparing with curcumin on ROS and NO production in LPSstimulated human THP-1 monocytic leukemia cells [20].…”

Section: Discussionmentioning

confidence: 99%

Stir-Fry Chicken with Green Curry Suppresses Inflammatory Gene Expression by Lipopolysaccharide-Induced Murine Macrophages

Charoenkiatkul¹,

Muangnoi²,

Chingsuwanrote³

et al. 2011

FNS

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Untitled

Cited by 279 publications

References 34 publications

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

Effect of Quercetin in the UV-Irradiated Human Keratinocyte HaCaT Cells and A Model of Its Binding To p38 MAPK

Stir-Fry Chicken with Green Curry Suppresses Inflammatory Gene Expression by Lipopolysaccharide-Induced Murine Macrophages

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