397 Colonic Derived Propionate As Substrate for Gluconeogenesis: An In Vivo Stable Isotope Study in Humans

Boets, Eef; Deroover, Lise; Luypaerts, Anja; Gomand, Sara; Mooter, Guy Van den; Annaert, Pieter; Delcour, Jan A.; Verbeke, Kristin

doi:10.1016/s0016-5085(15)30291-2

Cited by 1 publication

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“…In the epithelial cells, butyrate is transformed into acetyl-CoA, and enters tricarboxylic acid (TCA) cycle in the mitochondria to produce ATP, which is consumed by the colon epithelial cells. The portion of butyrate which is not utilized by epithelial cells can reach to the liver via portal circulation, where it is metabolized into acetyl-CoA and becomes a substrate for fatty acids, cholesterol, and ketone bodies by hepatocytes [21,31]. The plasma concentration of butyrate is very low compared to colonic levels, only 2% of butyrate enters systemic circulation, being utilized by other tissues and cells [31].…”

Section: Butyrate Production Absorption and Metabolismmentioning

confidence: 99%

“…The portion of butyrate which is not utilized by epithelial cells can reach to the liver via portal circulation, where it is metabolized into acetyl-CoA and becomes a substrate for fatty acids, cholesterol, and ketone bodies by hepatocytes [21,31]. The plasma concentration of butyrate is very low compared to colonic levels, only 2% of butyrate enters systemic circulation, being utilized by other tissues and cells [31]. The remaining SCFAs including butyrate are excreted through the lungs and urine.…”

Section: Butyrate Production Absorption and Metabolismmentioning

confidence: 99%

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Gut Microbial Metabolite Butyrate and its Therapeutic Role in Inflammatory Bowel Disease

Recharla¹,

Geesala²,

Shi³

2023

Preprint

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Intestinal commensal microbes, called the gut microbiota, play a critical role in host immune homeostasis through active microbial metabolites and innate and adaptive immune responses. Dysbiosis or imbalance of the gut microbiota composition is associated with inflammatory bowel disease (IBD) which includes Crohn’s disease and ulcerative colitis. The incidence and prevalence rates of IBD have been increasing worldwide. It is well recognized that butyrate, a microbial metabolite of diet fibers, is a major energy source for colonocytes and plays a crucial role in regulating immune function and maintaining epithelial barrier function and intestinal homeostasis. Emerging evidence suggests that butyrate might be a potential therapeutic agent to treat IBD. In this review, we discuss about gut microbial metabolites, particularly butyrate, the synthesis and metabolism of butyrate, mechanisms of butyrate in immune and epithelial barrier function. Furthermore, we review the current research on various therapeutic implications of butyrate in IBD.

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Section: Butyrate Production Absorption and Metabolismmentioning

confidence: 99%