396 POSTER Human papillomavirus (HPV) infection, p53 overexpression and histopathologic factors in colorectal cancer

Motlagh, Ali Ghanbari; Azadeh, P; Hashemi, Mahmoud Reza; Molaei, M.; Fazlalizadeh, Abdolah; Alidoosti, A.; Ghaderi, Fereshteh; Noorinayaer, B.; Davaei, M

doi:10.1016/s1359-6349(07)70414-7

Cited by 7 publications

(14 citation statements)

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“…The most frequent infecting HPV type in patients with CRC was HPV-18 in keeping with previous studies (Lee et al, 2001;Motlagh et al, 2007;Giuliani et al, 2008). Furthermore, we detected HPV-45 and HPV-31, which have not been previously reported in patients with colorectal carcinoma in Iran but have been recognized as high-risk types in malignant diseases (Yahyapour et al, 2013).…”

Section: Discussionsupporting

confidence: 89%

“…In comparison with this study, Damin et al (2007), Chen et al (2012) and Burnett-Hartman et al (2013) found HPV-16 as the most frequently detected HPV type in patients with CRC. Therefore, this study supports the hypothesis that expresses the different frequency patterns of HPV infection according to geographical variations and ethnicity of the populations (Jung et al, 2004;Chansaenroj According to Table 3, analysis of medical data in infected patients with CRC in compare to non-infected patients with CRC explained a possible association between high-risk types of HPV infections and accession Gillison and shah (2003), Chen et al (2012), Hamid and Mustafa (2012), Ghasemian et al (2013), Zandberg et al (2013) in comparison with results from Motlagh et al (2007), Giuliani et al (2008) investigate the ability of HPV infection to induce advanced stages of cancer in different malignancies. Furthermore, this study highlights the impact of high-risk types of HPV infection in distant metastasis and malignant lymph nodes invasion in compare with non-infected patients, which have been previously reported in several investigations (Chen et al, 1993;Gillison and shah, 2003;Bognar et al, 2008;McHugh et al, 2009;Zandberg et al, 2013).…”

Section: Discussionsupporting

confidence: 84%

“…This is in keeping with al. (2011) and Burnett-Hartman et al (2013), but some incidence of colorectal carcinoma (Bodaghi et al, 2005;Damin et al, 2007;Motlagh et al, 2007;Chen et al, 2012). This diversity has been explained according to possibility of contamination in sample preparation and testing and different frequency of HPV infection between populations which may be affected of high-risk sexual behaviors (Bodaghi et al, 2005;Burnett-Hartman et al, 2008;Burnett-Hartman et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer is the third leading cause of cancer dependent death in the world and there are one million new cases diagnosed per year (Burnett-Hartman et al, 2008;Giuliani et al, 2008) and also colorectal cancer is the third common cancer in Iranian population (Motlagh et al, 2007). It is a complex of multistep and multifactorial events, as an interaction between environmental and life style, sequential genetic alternations and viral infection (Giuliani et al, 2008;Doosti et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

Ranjbar¹,

Saberfar²,

Shamsaie³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

Ranjbar¹,

Saberfar²,

Shamsaie³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Damin et al found HPV-16 as the most frequently detected HPV type in patients with CRC 68.3% (41 out of 60 cases) 73% (8 out of 11 cases) respectively 10,14 . But Lee et al showed high frequency HPV18 infection in patients with CRC in Taiwan (84% 16 out of 19 cases, 90% 19 out of 21 cases) 15,16 . However Cheng et al have shown that HPV16 infection is common in Taiwanese patients with CRC (70% 26 out of 37 cases, 81.5% 31 out of 38 cases, 100% 41 out of 41 cases respectively) 12,17,18 .…”

Section: Disclosurementioning

confidence: 98%

Detection of Human Papilloma Virus in Colorectal Cancer by Polymerase Chain Reaction Technique in A Tertiary Care Hospital of Bangladesh

Das¹,

Hossain²,

Nasreen³

et al. 2019

Chatt Maa Shi Hosp Med Coll J

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Background: Human Papilloma Virus (HPV) infection is associated with the development of several cancers, including oral, esophageal, skin, lung, and uterine cervix. Association of HPV and colorectal cancers remains controversial. The aim of this study was to evaluate the association between HPV infection and colorectal cancer in Chattogram of Bangladesh. Materials and methods: The study was carried out in the Department of Pathology, Chattogram Medical College, Bangladesh over a period of one year from July, 2013 to June, 2014. A total of 60 cases were included in the study during the time period. Histopathological type and grading was done. HPV type 16 and 18 DNA was examined from all samples by means of Real Time PCR using type specific primer named E7 protein. Finally association between HPV types 16/18 with colorectal carcinoma was assessed by Chi-square (c2) test. Results: The mean age of 60 patients was 45.35 years (Range 17-75 years). Rectum was the common site of tumour 26 (43.3%). HPV type 16 and 18 was detected in 25 (41.7%) cases, out of whom 24 (96%) were associated with HPV16, and only one case was both HPV type 16 and 18. As regarding histological type, out of 25 cases 21 (84%) cases of adenocarcinoma, 3 (12%) case of signet ring carcinoma and only 1 (1.6%) case of mucinous carcinoma were positive for HPV. Conclusion: HPV specially subtype 16, may play a role in the oncogenesis of Colorectal Carcinoma. Chatt Maa Shi Hosp Med Coll J; Vol.18 (1); Jan 2019; Page 44-48

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Molecular Localization of Human Papilloma Virus genotypes (16, 18, and 6/11) in Patients with Colorectal Cancer by DNA- Insitu Hybridization

Jasim¹

2018

IJCMG

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Human papilloma viruses (HPV) have been detected in several types of cancers. Over the last few years, a possible correlation between HPV infection and colorectal cancer has been suggested. The aim of this study was to investigate the association between human papilloma virus (HPV) infection and colorectal cancer. To determine the relationship between HPV and colorectal adenocarcinoma, a retrospective study was done. This study was carried out on 50 patients with hisopathologically confirmed primary colorectal cancer. Two samples were collected from each patient: one sample from the tumor site and the other one from adjacent normally appearing colorectal tissues, as well as ten (20) colorectal tissues from control individuals with no cancer. In situ hybridization (ISH) was used to detect HPV DNA (HPV 16 and 18 DNA ISH and 6/11 DNA CISH) in colorectal tissues. HPV 16 was detected in 16(32%) of tumor samples, and in 7 (14%) of adjacent normal tissues, and in additionally two cases of apparently healthy group gave positive results for it. HPV 18 was detected in 11 (22%) of tumor samples and in 6 (12%) of adjacent normal tissue. HPV 6/11 was detected in 24 (48%) of tumor samples and in 7 (14%) of adjacent normal tissue.Our results suggest that colorectal HPV infection is common in patients with adenocarcinoma colorectal, albeit at a low DNA copy number, with HPV16 being the most prevalent type. HPV infection may play a role in colorectal carcinogenesis

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396 POSTER Human papillomavirus (HPV) infection, p53 overexpression and histopathologic factors in colorectal cancer

Cited by 7 publications

References 0 publications

The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

Detection of Human Papilloma Virus in Colorectal Cancer by Polymerase Chain Reaction Technique in A Tertiary Care Hospital of Bangladesh

Molecular Localization of Human Papilloma Virus genotypes (16, 18, and 6/11) in Patients with Colorectal Cancer by DNA- Insitu Hybridization

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