Abstract:Objectives
The role of iron on Reactive Oxygen Species (ROS) generation by catalysing Fenton reaction have been suggested by many studies as an important factor in increasing oxidative DNA damage. Mitochondria represents an important biological source and target of ROS that induce 8-hydroxy-2̀’-deoxyguanosine (8-OHdG) formation. Occupational exposure to metal rich air particles, as reported in steel production process, constitutes an important source of metal exposure, in particular to iron.
Methods
We measu… Show more
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