392P Clinical data from the real world: Efficacy analysis of ceritinib (450mg) in ALK-positive non-small cell lung cancer patients with brain metastases in China

Qiu, Zhixin; Wang, K.; Huang, Meijuan; Yu, Min; Liu, C.; Xian, X.

doi:10.1016/j.annonc.2020.10.386

Cited by 1 publication

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“…JournaloftheNationalCancerCenterpublisheditsfirstonline articleentitled"StatisticsofCancerIncidenceanddeathinChina in2015"byAcademicianHejie'steam [1] .Basedonthedataof 368high-qualitysurveillancesitesselectedfrom501cancersur-veillancesitesinChina,coveringapopulationof310million,ac-countingfor22.52%ofthetotalpopulationin2015.Thearticle comprehensivelyreflectstheepidemiccharacteristicsandregional differencesofcancerspectruminChina,includingtheincidence rateofbraintumorwas4.9casesper100,000,andthemortality ratewas2.9casesper100,000.In2020,56,000peopledied, rankingamongthetop10cancerdeathsinChina [2] .Amongall kindsofbrainmalignancies,gliomaisthemostmalignantglioma amongastrocytomas.Itisatumorproducedbyglialcellsortheir precursorsinthecentralnervoussystem(CNS) [3] .Itisextremely invasiveandthemostcommonCNSmalignanttumor,accounting for47%ofsuchtumors [4][5][6] .Themediansurvivalforthistypeof cancerisjust15-17months,andlessthan5%ofpatientswith glioblastomawhoreceivestandardtreatmentsurvivefiveyears. Gliomaoccursfrequentlyinteenagersandhasagreatimpacton societyandfamily [4] .OnMarch4,2021,thetopic"Six-year-old GirlLinNuoendiedanddonatedorganstosave5peopleinFuzhou,Fujianprovince"waslistedinthehotsearchlistonWeibo news,whichwasread210milliontimes,liked290,000timesand triggered33,000discussionswithinhalfaday Researchers are extensively carrying out basic research on glioma animal model [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Human Glioma Nude Mouse Xenograft Model <i>in situ</i>

Wang¹,

Kong²,

Chen³

et al. 2021

jbyyj

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Backgrounds: Surgery and chemotherapy are difficult because of the specific location of the glioma. The establishment of a suitable in situ model of glioma is the premise of the treatment of glioma. 8 week-old female BALB/c nude mice were chose to establish the glioma model. Methods: For the orthotopic glioma mice model, 1 × 105 cells/5 μL U87-MG-Luc or U87-MG cells which were trypsinized and resuspended in sterile PBS were slowly injected into the right corpus striatum (1.8 mm lateral, 0.6 mm anterior to the bregma and 3.0 mm in depth) by a stereotactic fixation device using a mouse adaptor. Results: The othotopic U87 glioma mice model identified by imaging on IVIS Spectrum and magnetic resonance imaging after 2 weeks from surgery. H&E-stained tumor sections in brain of the mice model were also observed. Conclusions: After identification, the glioma mouse xenograft in situ model obtained could be used in the evaluation system of therapeutic drugs or methods.

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Section: Introductionmentioning

confidence: 99%