392. A new synthetical route from indan-1-ones to 3-oxyindane-1-carboxylic acids

Abstract

In a new approach to substitution in the 3-position of the indan-l-ones, 3-chloroindene was converted, via its lithium derivative, into 3-chloroindenel-carboxylic acid. From the latter, 3-oxoindane-1-carboxylic acid and indane-1-carboxylic acid were readily obtained. The same sequence applied to 5-methoxyindan-l-one, gave 6-methoxyindane-l-carboxylic acid in small yield. 3-BromoindeneJ prepared by an improved method, failed to give an ethylenic Grignard reagent.