39. First implementation in France of nonpalpable breast lesions localization using an 125 I-seed (radioactive)

Hoog, Christopher; Dejean, C.; Koulibaly, Malick; Chapellier, C.; Barranger, Emmanuel

doi:10.1016/j.ejmp.2017.10.064

Cited by 1 publication

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“…But in France, the gold standard technique remains implanting a metal wire from the lesion to the skin. The Antoine Lacassagne Centre (Nice, France) is the first French hospital authorised to offer an alternative solution with an iodine-125-seed ( 125 I-seed) implanted into the tumour [6]. The two techniques are currently compared within the randomised prospective clinical trial "IODINE BREAST" (NCT02759133).…”

Section: Introductionmentioning

confidence: 99%

Comparison of 3 γ-probes for simultaneous iodine-125-seed and technetium-99m breast cancer surgery: NEMA standard characterisation with extended processing

Hoog¹,

Koulibaly²,

Dejean³

et al. 2020

EJNMMI Phys

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Iodine-125 (125 I) seeds can be used as landmarks to locate non-palpable breast lesions instead of implanting metal wires. This relatively new technique requires a nuclear probe usually used for technetium-99m (99m Tc) sentinel node detection. This study aimed to compare the performances of different probes and valid the feasibility of this technique, especially in the case of simultaneous 125 I-seed and 99m Tc breast cancer surgery. Methods: Three probes with different features (SOE-3211, SOE-3214 and GammaSUP-II) were characterised according to the NEMA NU3-2004 standards for a 99m Tc source and a 125 I-seed. Several tests such as sensitivity, linearity or spatial resolution allowed an objective comparison of their performances. NEMA testing was extended to work on signals discrimination in case of simultaneous detection of two different sources (innovative figure of merit "Shift Index") and to assess the 99m Tc scatter fraction, a useful parameter for the improvement of the probes in terms of detector materials and electronic system. Results: Although the GammaSUP-II probe saturated at a lower activity (1.6 MBq at 10 mm depth), it allowed better sensitivity and spatial resolution at the different NEMA tests performed with the 99m Tc source (7865 cps/MBq and 15 mm FWHM at 10 mm depth). With the 125 I-seed, the GammaSUP-II was the most sensitive probe (3106 cps/MBq at 10 mm depth) and the SOE-3211 probe had the best spatial resolution (FWHM 20 mm at 10 mm depth). The SOE-3214 probe was more efficient on discriminating 125 I from 99m Tc in case of simultaneous detection. The SOE probes were more efficient concerning 99m Tc scatter fraction assessments. The SOE-3211 probe, with overall polyvalent performances, seemed to be an interesting trade-off for detection of both 125 I and 99m Tc.

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Section: Introductionmentioning

confidence: 99%