383: Which Definition of PSA Doubling Time or Velocity best Predicts Outcome after Radical Prostatectomy?

O’Brien, Matthew F.; Feam, Paul A.; Smith, Brandon; Stasi, Jason; Serio, Angel M.; Eastham, James A.; Lilja, Hans

doi:10.1016/s0022-5347(18)30636-0

Cited by 2 publications

(2 citation statements)

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“…In our first study, we found that PSA velocity did not improve on PSA alone for predicting long-term risk of prostate cancer; 11 in the second study, PSA dynamics did not help predict either recurrence or prostate cancer mortality after radical prostatectomy. 12 This led us to reassess the evidence base for pretreatment PSA velocity and doubling time as prostate cancer markers. Here, we report a systematic review of studies investigating pretreatment PSA dynamics.…”

Section: Journal Of Clinical Oncology O R I G I N a L R E P O R Tmentioning

confidence: 99%

Systematic Review of Pretreatment Prostate-Specific Antigen Velocity and Doubling Time As Predictors for Prostate Cancer

Vickers

Savage

O’Brien

et al. 2009

JCO

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222

129

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Section: Journal Of Clinical Oncology O R I G I N a L R E P O R Tmentioning

confidence: 99%

Systematic Review of Pretreatment Prostate-Specific Antigen Velocity and Doubling Time As Predictors for Prostate Cancer

Vickers

Savage

O’Brien

et al. 2009

JCO

Self Cite

222

129

View full text Add to dashboard Cite

show abstract

“…In posttreatment patients, PSA levels derive mainly (and after radical prostatectomy completely) from cancer, and therefore PSA dynamics would be expected to match cancer growth more closely [45–47]. Two recent studies of PSA dynamics before treatment [25,48] yielded no evidence that the rate of change of PSA was of value. In addition, a recent systematic review analyzed 87 studies investigating pretreatment PSA velocity or doubling time in early-stage PCa [49••].…”

Section: Prostate-specific Antigen Kineticsmentioning

confidence: 99%

Early prostate-specific antigen changes and the diagnosis and prognosis of prostate cancer

George

Matikainen

Lilja

2009

Current Opinion in Urology

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Purpose of review-To delineate how recent findings on prostate-specific antigen (PSA) can improve prediction of risk, detection, and prediction of clinical endpoints of prostate cancer (PCa).Recent findings-The widely used PSA cut-point of 4.0 ng/ml increasingly appears arbitrary, but no cut-point achieves both high sensitivity and high specificity. The accuracy of detecting PCa can be increased by additional predictive factors and combinations of markers. Evidence implies that a panel of kallikrein markers improves the specificity and reduces costs by eliminating unnecessary biopsies. Large, population-based studies have provided evidence that PSA can be used to predict PCa risk many years in advance, improve treatment selection and patient care, and predict the risk of complications and disease recurrence. However, definitive evidence is currently lacking as to whether PSA screening lowers PCa -specific mortality.Summary-PSA is still the main tool for early detection, risk stratification, and monitoring of PCa. However, PSA values are affected by many technical and biological factors. Instead of using a fixed PSA cut-point, using statistical prediction models and considering the integration additional markers may be able to improve and individualize PCa diagnostics. A single PSA measurement at early middle age can predict risk of advanced PCa decades in advance and stratify patients for intensity of subsequent screening.

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383: Which Definition of PSA Doubling Time or Velocity best Predicts Outcome after Radical Prostatectomy?

Cited by 2 publications

References 0 publications

Systematic Review of Pretreatment Prostate-Specific Antigen Velocity and Doubling Time As Predictors for Prostate Cancer

Systematic Review of Pretreatment Prostate-Specific Antigen Velocity and Doubling Time As Predictors for Prostate Cancer

Early prostate-specific antigen changes and the diagnosis and prognosis of prostate cancer

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