383. Einflu� der intermittierenden Kompression und von k�rperlichem Training auf verschiedene Parameter der Blutgerinnung und Fibrinolyse

Abstract

Summary. In 30 patients with varicosis intermittent high-pressure compression of the leg was applied before a stripping operation and the fibrinolytic activity of intraoperatively obtained vein segments was studied histochemically. In comparison with 10 non-treated patients the fibrinolytic activity of the vessel wall was markedly increased. The systemic enhancement of fibrinolysis was only seen when the blood was drawn from the treated extremity. In addition, after active exercise, i.e. moutaineering and cross-country skiing under competition conditions, a significant activation of fibrinolysis and coagulation was seen in the plasma of the volunteers.

Haematological Effects of Intermittent Pneumatic Compression for Deep Vein Thrombosis Prophylaxis

“…In four separate cases there were two publications relating to the same overall study and the same tests. 6,7,14,15,24,25,29,30 In two separate cases there were three 18,21,23 or two 40,42 reports that appear to relate to the same overall study, but report different tests and have been treated separately. One report was of the use of elastic bandages 54 despite it being included in a previous review of the physiological effects of IPC.…”

“…Some were not primarily designed to assess the haematological effects of IPC, 28,39,43 and in others the IPC use was combined with other types of prophylaxis 9,27,39,41 and therefore any effect cannot only be attributed to IPC. The trials are of two types: defined short-term use of IPC (10 minutes to 2 hours) in healthy volunteers 10,16,17,31,33,34,36,37,[44][45][46][47] and patients, 10,12,14,15,18,19,21,23,34,36 and longer-term and often variable or less well defined use during and postsurgery. [6][7][8][9]11,13,20,22,[24][25][26][27][28][29][30]32,35,[38][39][40]…”

“…The trials are of two types: defined short-term use of IPC (10 minutes to 2 hours) in healthy volunteers 10,16,17,31,33,34,36,37,[44][45][46][47] and patients, 10,12,14,15,18,19,21,23,34,36 and longer-term and often variable or less well defined use during and postsurgery. [6][7][8][9]11,13,20,22,[24][25][26][27][28][29][30]32,35,[38][39][40][41][42][43][48][49][50][51][52] All the trials took blood samples pre-and post-intervention, but only a minority had a true control group,…”

“…There is probably sufficient evidence to conclude that IPC increases global fibrinolytic activity. It is the conclusion of several controlled trials, [6][7][8]14,15,22,45,51 using a variety of IPC types and subject groups. However, some of the older global tests are considered to have poor reproducibility, to the extent of possibly affecting the outcome of trials.…”

“…8 There is only one example 34 of increases in fibrin plate lysis area 60 in the reports included in this review, with two others not showing a significant change. 9,12 An increase in fibrinolytic activity has been shown with IPC 22 using a radioactive clot lysis technique 61 and also in excised varicose veins after IPC 14,15 using fibrinolytic autographs. 62…”