381P Efficacy of ginger (G) in control of chemotherapy induced nausea and vomiting (CINV) in breast cancer patients (BCPs) receiving doxorubicin-based chemotherapy (DBCT)

Ansari, Mansour; Mohammadianpanah, Μohammad; Omidvari, Shapour; Ahmad, Mansoor; Ahmadloo, Niloofar; Nasrollahi, Hamid; Hamedi, Seyed Hasan; Porouhan, Pejman

doi:10.1093/annonc/mdv531.14

Cited by 19 publications

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“…After excluding duplicates, the 42 remaining studies were screened by their title and abstract of which 33 were excluded due to the following reasons: (a) 16 studies were review articles, (b) 13 of them were not relevant in exposure or outcome, (c) one study was animal based, (d) one study was a conference paper, and (e) two papers were commentary or editorial. Finally, nine trials (Ansari et al, ; Arslan & Ozdemir, ; Lua, Salihah, & Mazlan, ; Panahi et al, ; Ryan et al, ; Salihah, Mazlan, & Lua, ; Sanaati et al, ; Thamlikitkul et al, ; Yekta et al, ) were included in this review, which were published between 2012 and 2017 (Table ). Included studies were conducted in Turkey (one study), Malaysia (two studies), Iran (four studies), United States (one study), and Thailand (one study).…”

Section: Resultsmentioning

confidence: 99%

“…The five studies included in this systematic review were double blinded randomized controlled trials (Ansari et al, ; Ryan et al, ; Sanaati et al, ; Thamlikitkul et al, ; Yekta et al, ). A cross‐over design was applied in three studies (Lua et al, ; Salihah et al, ; Thamlikitkul et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…Most of the participants were under combination chemotherapy regimens, such as those based on doxorubicin (Ansari et al, ) and adriamycin–cyclophosphamide (Thamlikitkul et al, ), which are moderate to highly emetogenic (Arslan & Ozdemir, ; Panahi et al, ; Thamlikitkul et al, ). Three studies did not provide information about chemotherapy regimens, although the administration of antiemetic drugs implied that the chemotherapy regimens applied induced a moderate to high degree of nausea in patients (Ryan et al, ; Sanaati et al, ; Yekta et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…Clinical studies suggest that aromatherapy as a complementary therapy has beneficial effects in reducing nausea (Steflitsch & Steflitsch, ). In five studies, subjects received a 5‐HT3 receptor antagonist and dexamethasone to prevent CINV (Ansari et al, ; Panahi et al, ; Ryan et al, ; Thamlikitkul et al, ; Yekta et al, ). Sanaati et al used dexamethasone, metoclopramide and aprepitant as a routine antiemetic regimen (Sanaati et al, ).…”

Section: Resultsmentioning

confidence: 99%

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The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

Totmaj

Emamat

Jarrahi

et al. 2019

Phytotherapy Research

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Breast cancer is the most commonly diagnosed cancer and is the leading cause of mortality due to all types of cancers among the female population worldwide. Results of clinical trials investigating the effect of ginger on chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients are inconsistent. This study was aimed at obtaining a comprehensive overview of the current evidence regarding the effectiveness of ginger as an antiemetic modality for controlling CINV in breast cancer patients. All published randomized controlled trials in English were systematically searched on Google Scholar, PubMed, Scopus, and Cochrane search databases up to June 2018. The outcome variable of interest was severity and the frequency of nausea and vomiting in patients. A total of 50 studies were found through search databases. After excluding duplicates, the 42 remaining studies were screened, and finally, nine trials were included, which were published between 2012 and 2017.Two studies have examined the effect of ginger on the frequency of nausea, five studies on the frequency of vomiting, seven studies on the severity of nausea, and three studies on severity of vomiting. A study evaluated the effectiveness of ginger in improving dietary intake in CINV. Our investigation suggests that ginger may reduce nausea in the acute phase of chemotherapy in patients with breast cancer.The effect of ginger on nausea and vomiting in other conditions requires more high-quality clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

Totmaj

Emamat

Jarrahi

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The standard of care for chemotherapy-induced vomiting is antiemetics, most notably serotonin (5-HT3) receptor antagonists and glucocorticoids, such as dexamethasone; however, efforts to control nausea have not been successful (Bloechl-Daum, Deuson, Mavros, Hansen, & Herrstedt, 2006;Herrstedt & Roila, 2008). The summary of studies evaluating the effects of ginger consumption on chemotherapy-related nausea and vomiting is shown in Table 2 ( Ansari et al, 2016;Arslan & Ozdemir, 2015;Fahimi et al, 2011;Manusirivithaya et al, 2004;Marx et al, 2013;Panahi et al, 2012;Pillai, Sharma, Gupta, & Bakhshi, 2011;Ryan et al, 2012;Sanaati, Najafi, Kashaninia, & Sadeghi, 2016;Sontakke, Thawani, & Naik, 2003;Thamlikitkul et al, 2017;Zick et al, 2009). Nausea and vomiting can occur after surgery, medications, or even exercise.…”

Section: Naus E a And Vomitingmentioning

confidence: 99%

Ginger in gastrointestinal disorders: A systematic review of clinical trials

Bodagh

Maleki

Hekmatdoost

2018

Food Science & Nutrition

101

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Ginger, the rhizome of Zingiber officinale, which is used as a spice globally has a long history of medicinal use that stimulates investigators to assess its potential roles as an adjuvant therapy or alternative medicine in a range of diseases. Anti‐inflammatory, antioxidant, antitumor, and antiulcer effects of ginger have been proven in many scientific studies, and some of the ancient applications of ginger as a home remedy has been confirmed in human. In this review, we summarized the current evidence on the effects of ginger consumption on gastrointestinal disorders based on clinical trials. Our data indicate that divided lower daily dosage of 1500 mg ginger is beneficial for nausea relief. Because of limited number of studies on some other gastrointestinal disorders, the results may not be as much powered as to find significant results. Therefore, more extensive and well‐controlled human studies of ginger or its standard extracts are required to demonstrate its efficacy as a gastroprotective agent. Dose‐finding studies should be undertaken to accurately determine the effective dose and preparation of ginger in further clinical trials protocol.

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Medicinal herbs in treating chemotherapy‐induced nausea and vomiting: A review

Rajabalizadeh

Rahbardar

2022

Phytotherapy Research

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Cancer development entangles with mutation and selection for cells that progressively increase capacity for proliferation and metastasis at the cellular level. Surgery, chemotherapy, and radiotherapy are the standard treatments to manage several types of cancer. Chemotherapy is toxic for both normal and cancer cells and can induce unfavorable conditions, such as chemotherapy‐induced nausea and vomiting (CINV), that reduce patients' quality of life. Emesis after chemotherapy is categorized into two classes acute and delayed. Since ancient times, herbal medicines have been used in various cultures to manage stomachache, vomiting, and nausea. In this manuscript, the antiemetic mechanisms of several herbal medicines and their preparations such as Zingiber officinale (5‐HT, NK‐1 receptor and muscarinic antagonist activity), Mentha spicata (5‐HT antagonist activity), Scutellaria baicalensis (antioxidant activity), Persumac (useful in delayed phase through antioxidant, anti‐inflammatory, and anti‐contractile properties) and Rikkunshito (supportive in acute and delayed phase through 5‐HT receptor antagonist activity) have been reviewed to show their potential effects on decreasing CINV and attract scientists attention to formulate more herbal medicine to alleviate CINV in cancer patients. However, it is crucial to say that additional high‐quality investigations are required to firmly verify the clinical effectiveness and safety of each plant/compound.

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381P Efficacy of ginger (G) in control of chemotherapy induced nausea and vomiting (CINV) in breast cancer patients (BCPs) receiving doxorubicin-based chemotherapy (DBCT)

Cited by 19 publications

References 0 publications

The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

Ginger in gastrointestinal disorders: A systematic review of clinical trials

Medicinal herbs in treating chemotherapy‐induced nausea and vomiting: A review

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