380 Baseline Gastric Emptying and its Change in Response to Diverse Endoscopic Bariatric Therapies Predict Weight Change After Intervention

Dayyeh, Barham K. Abu; Woodman, George; Acosta, Andrés; Lopes, Guilherme S.; Gostout, Christopher J.; Moura, Eduardo G. de; Gómez, Victoria; Martins, Bruno da Costa; Topazian, Mark; Camilleri, Michael

doi:10.1016/s0016-5085(16)30405-x

Cited by 8 publications

(5 citation statements)

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“…In the future, physiological predictors of intolerance and response will likely be identified to individualize patient care using office based tools. (28) Once such tool could be the recently FDA approved 13C-Spirulina Gastric Emptying Breath Test (GEBT) (Cairn Diagnostics, Brentwood, TN). (29)…”

Section: Discussionmentioning

confidence: 99%

Single Fluid-Filled Intragastric Balloon Safe and Effective for Inducing Weight Loss in a Real-World Population

Vargas

Pesta

Bali³

et al. 2018

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 99%

Single Fluid-Filled Intragastric Balloon Safe and Effective for Inducing Weight Loss in a Real-World Population

Vargas

Pesta

Bali³

et al. 2018

Clinical Gastroenterology and Hepatology

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“… 51 After 36 months with Orbera, patients had a long-term weight loss of 6%. 50 , 52 A subsequent study in the United States showed a similar reduction in TBW (10.54%) than the control group. 53 The Orbera is relatively safe, with nausea and vomiting as the most common adverse events.…”

Section: Society Guidelinesmentioning

confidence: 81%

“…Patients who received Orbera showed a 47% delay in gastric emptying and a 32.1% decrease in excess body weight 6 months after implantation. 50 These balloons are temporary, placed for 6 months, and can be replaced later. The attained weight loss was corresponding to the extent of gastroparesis achieved that, in turn, varied with the volume of the balloon.…”

Section: Society Guidelinesmentioning

confidence: 99%

Endobariatric procedures for obesity: clinical indications and available options

Goyal

Kopel

Perisetti

et al. 2021

Clin Med Insights Gastroenterol

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Obesity remains a growing public health epidemic that has increased healthcare costs and related comorbidities. Current treatment guidelines encourage a multidisciplinary approach starting from patient selection, interventions, and long-term follow-up to maintain weight loss. However, these conservative interventions are largely ineffective at reducing body weight due to low adherence to the treatment regimen. Recently, endoscopic bariatric therapies have become an attractive alternative to traditional invasive bariatric surgeries due to their improved efficacy, safety, and cost-effectiveness. Endoscopic bariatric therapies include intragastric balloon placement, endoscopic sleeve gastroplasty, gastric bypass revision, and aspiration therapy. These procedures fall into two separate categories depending on the primary mechanism involved: restrictive or malabsorptive. Restrictive methods, such as the Orbera® and ReShape™ intragastric balloons, increase satiation and delay gastric emptying while decreasing the amount of food that can be ingested. In contrast, malabsorptive devices, such as the EndoBarrier®, interfere with the small intestine’s ability to absorb food while restoring normal gastrointestinal hormone levels regulating satiation. Together, these techniques provide useful alternatives for patients in whom pharmacological or lifestyle modifications have proven ineffective. Despite these advantages, the long-term effects of these procedures on metabolic changes remain to be studied. Furthermore, the management of complications from these procedures continues to evolve. In this review, we aim to elaborate on the clinical indications and efficacy of the endobariatric procedures, together with various types of available endoscopic bariatric therapy procedures.

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“…The era of personalised obesity management is quickly approaching with office-based tools to predict and prognostic patient’s response to lifestyle interventions, medications and endoscopic bariatrics 5 6 9–11. AT is an option for patients with class II–III obesity with reservations about bariatric surgery.…”

Section: Discussionmentioning

confidence: 99%

Accelerated gastric emptying is associated with improved aspiration efficiency in obesity

Vargas

Storm

Bazerbachi

et al. 2019

BMJ Open Gastroenterol

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BackgroundThe overall effectiveness of aspiration therapy (AT) for obesity relies on optimal aspiration timing after a meal, which can vary depending on a patient’s rate of gastric emptying (GE). Our aim was to identify if baseline GE rates were associated with differences in aspiration efficiency (AE).MethodsSubjects from an ongoing AT clinical trial were enrolled in this study. AE was calculated as the absolute gastric residual and calories aspirated at 20 and 40 min. Participants were then divided by baseline GE rate into two groups (slow vs fast). Wilcoxon rank-sum test was used to compare AE at 20 and 40 min between the groups. Exploratory linear regression was used to assess relationship between GE and AE.Results7 patients (85% female) were coenrolled in the study. Mean age and body mass index were 39.8±9.44 and 43±5, respectively. AE did not significantly differ between the 20 and 40 min time points for the group as a whole (34.3% vs 36.9%; p>0.5). However, those with fast GE aspirated more calories than those with slow GE (20 min: 200 kcal vs 72.5 kcal; 40 min: 154 kcal vs 63 kcal) (p=0.05). On linear regression, delayed GE was associated with poorer aspiration (20 min: β=−107 calories; p=0.019; R2=0.7). 4/7 patients had significant differences in residual/caloric aspiration across the two time points.ConclusionPatients undergoing AT may benefit from a GE test to optimise their AE. Paradoxically faster GE times saw better aspiration. Prospective studies are revealing a personalised approach to obesity.

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380 Baseline Gastric Emptying and its Change in Response to Diverse Endoscopic Bariatric Therapies Predict Weight Change After Intervention

Cited by 8 publications

References 0 publications

Single Fluid-Filled Intragastric Balloon Safe and Effective for Inducing Weight Loss in a Real-World Population

Single Fluid-Filled Intragastric Balloon Safe and Effective for Inducing Weight Loss in a Real-World Population

Endobariatric procedures for obesity: clinical indications and available options

Accelerated gastric emptying is associated with improved aspiration efficiency in obesity

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