[38] Antioxidant effects of carotenoids in Vivo and in Vitro: An overview

Palozza, Paola; Krinsky, Norman I.

doi:10.1016/0076-6879(92)13142-k

Cited by 425 publications

(219 citation statements)

References 59 publications

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“…In humans, β-carotene is the precursor for vitamin A; it may function as an anti-oxidant, has protective properties against cancer and stimulates the immune system (Palozza and Krinsky, 1992).…”

Section: Introductionmentioning

confidence: 99%

Heterologous carotenoid production in Saccharomyces cerevisiae induces the pleiotropic drug resistance stress response

Verwaal

Jiang

Wang

et al. 2010

Yeast

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To obtain insight into the genome-wide transcriptional response of heterologous carotenoid production in Saccharomyces cerevisiae, the transcriptome of two different S. cerevisiae strains overexpressing carotenogenic genes from the yeast Xanthophyllomyces dendrorhous grown in carbon-limited chemostat cultures was analysed. The strains exhibited different absolute carotenoid levels as well as different intermediate profiles. These discrepancies were further sustained by the difference of the transcriptional response exhibited by the two strains. Transcriptome analysis of the strain producing high carotenoid levels resulted in specific induction of genes involved in pleiotropic drug resistance (PDR). These genes encode ABC-type and major facilitator transporters which are reported to be involved in secretion of toxic compounds out of cells. β-Carotene was found to be secreted when sunflower oil was added to the medium of S. cerevisiae cells producing high levels of carotenoids, which was not observed when added to X. dendrorhous cells. Deletion of pdr10, one of the induced ABC transporters, decreased the transformation efficiency of a plasmid containing carotenogenic genes. The few transformants that were obtained had decreased growth rates and lower carotenoid production levels compared to a pdr5 deletion and a reference strain transformed with the same genes. Our results suggest that production of high amounts of carotenoids in S. cerevisiae leads to membrane stress, in which Pdr10 might play an important role, and a cellular response to secrete carotenoids out of the cell.

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Section: Introductionmentioning

confidence: 99%

Heterologous carotenoid production in Saccharomyces cerevisiae induces the pleiotropic drug resistance stress response

Verwaal

Jiang

Wang

et al. 2010

Yeast

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“…In contrast, there is considerable in vitro evidence for interaction of 13-carotene with free radicals [1][2][3][4][5], for its properties as a chain-breaking antioxidant [2] and in scavenging and quenching singlet oxygen [6][7][8][9]. 13-Carotene has also been reported to protect against photosensitivity diseases in humans [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities of carotenes and xanthophylls

et al. 1996

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The purpose of this study was to assess the relative antioxidant activities of a range of carotenes and xanthophylls through the extent of their abilities to scavenge the ABTS "+ radical cation. The results show that the relative abilities of the carotenoids to scavenge the ABTS "÷ radical cation are influenced by the presence of functional groups with increasing polarities, such as carbonyl and hydroxyl groups, in the terminal rings, as well as by the number of conjugated double bonds.

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“…Carotenoid pigments present in crude oils also have antioxidant activity, especially in the light, but also in vivo (PALOZZA & KRINSKY 1992). They are, however, almost completely removed in the course of oil refining (OOI et al 1996;FAESSELT 1998).…”

Section: Antioxidants In Crude and Refined Vegetable Oilsmentioning

confidence: 99%

Potential application of oilseeds as sources of antioxidants for food lipids - a review

Schmidt¹,

Pokorný²

2005

Czech J. Food Sci.

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Oilseeds and other sources of edible oils contain both less polar antioxidants soluble in the oil phase, and more polar antioxidants, better soluble in the aqueous phase. Oilseeds which are consumed directly as such or after roasting may be added to foods in order to increase their stability against oxidation. The liposoluble antioxidants are extracted in crude oil during oilseed processing, and they are partially recovered in deodorisation sludges. More polar antioxidants remain in expeller cakes or extracted meal, which may be also used as food additives to increase the oxidative stability of foods. Oilseed meal extracted with hydrocarbons may be subsequently extracted with more polar organic solvents to obtain concentrates of phenolic substances, mainly phenolic acids, lignans or flavonoids. These are more active antioxidants, but also more expensive. Pure isolated antioxidants from oilseeds should be tested for their safety. In comparison with synthetic antioxidants, natural antioxidants from oilseeds have several advantages, but also disadvantages. The application should be considered from several aspects, such as antioxidant activity, safety, availability, effect on sensory value, and price.

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[38] Antioxidant effects of carotenoids in Vivo and in Vitro: An overview

Cited by 425 publications

References 59 publications

Heterologous carotenoid production in Saccharomyces cerevisiae induces the pleiotropic drug resistance stress response

Heterologous carotenoid production in Saccharomyces cerevisiae induces the pleiotropic drug resistance stress response

Antioxidant activities of carotenes and xanthophylls

Potential application of oilseeds as sources of antioxidants for food lipids - a review

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