373 Dermatologists’ prescriptions of sedating antihistamines in older adults: Data from the national ambulatory health survey 2006-2015

Abstract

Most conclusions on LM have been drawn from research on invasive or lentigo maligna melanoma (LMM), with the inference that LM acts similarly to LMM. This study evaluates the epidemiologic characteristics of LM and the histopathologic characteristics of LM compared to LMM. A retrospective chart review of all cases of LM and LMM diagnosed at Rhode Island Hospital from 1980-2017 was evaluated. Rhode Island Hospital serves as a tertiary referral center for the entire state and serves a catchment area of 2 million people across 3 states. Demographic data was extracted, as well as histopathologic characteristics. Only cases of LM and LMM with histopathologic confirmation read by a pathologist or dermatopathologist were included for review. A total of 706 cases of LM and 43 cases LMM were evaluated. Compared to LMM patients, LM patients were more likely male (p¼.04), with tumors on the left side of the face (p¼.03). Compared to females with LM, males with LM were more likely to present with tumors on the scalp (p<.01), nose (p<.01), and ear (p<.01). Females with LM were more likely to present with tumors on the lower extremity when compared to males (p<.01). On histopathologic review, LM was less likely to show a lymphocytic response (p<.01) and have a concurrent lesion preset on the same slide (p<.01). For LMMs with concurrent lesions present on the same slide, the most common diagnoses were dysplastic nevi (5%) and keratinocyte carcinoma (26%). Several clinical differences exist between men and women with LM, and several histologic differences exist between LM and LMM.