36H: A Novel Potent Inhibitor for Antimelanogenesis

Lin, Li‐Ching; Chen, Chung‐Yi; Lin, Yun‐Sheng; Hwang, Byeong Hee; Wang, Tina Kaiting; Kuo, Yueh‐Hsiung; Wang, Hui‐Min David

doi:10.1155/2018/6354972

Cited by 17 publications

(21 citation statements)

References 30 publications

(49 reference statements)

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“…We followed the methods of Lin et al (2018). 1 Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) consisted an exclusive primer probe to generate fluorescence. It used a fluorescence detection technique that senses each cycle using a 7500 qRT-PCR System (Applied Biosystems, USA).…”

Section: Experimental Materials and Methodsmentioning

confidence: 99%

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism

et al. 2020

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In the melanin synthesis process, oxidative reactions play an essential role, and it is a good strategy to inhibit melanin production by reducing oxidative stress. Fullerene and its derivatives, or the complexes, were considered as strong freeradical scavengers, and we further applied multilayered sp 2 nanocarbons to discover melanin synthesis inhibitory mechanisms. In the present study, we used novel nanomaterials, such as multiwalled carbon nanotubes (MWCNTs), short-type MWCNTs, graphene oxide nanoribbons (GONRs), and short-type GONRs, as anti-oxidative agents to regulate melanin production. The results showed that GONRs had better anti-oxidative capabilities in intracellular and extracellular oxidative stress analysis platforms than others. We proposed that GONRs have oxygen-containing functional groups. In the 2′,7′-dichlorodihydrofluorescein diacetate assay, we found out GONR could chelate metal ions to scavenge reactive oxygen species. In the molecular insight view, we observed that these nanomaterials downregulated the melanin synthesis by decreasing microphthalmia-associated transcription factor-related gene expressions, and there were similar consequences in protein expressions. To sum up, GONRs is a potential agent as a novel antioxidant and skin-whitening cosmetology material.

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Section: Experimental Materials and Methodsmentioning

confidence: 99%

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism

et al. 2020

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“…Tyrosinase is the rate‐limiting enzyme for managing the production of melanin . Briefly, the samples were first dissolved in aqueous DMSO and cultured in L‐tyrosine (2.5 mg mL −1 ) with phosphate buffer (pH 6.8, 50 mmol L −1 ).…”

Section: Methodsmentioning

confidence: 99%

“…Tyrosinase is the rate-limiting enzyme for managing the production of melanin. 23 Briefly, the samples were first dissolved in aqueous DMSO and cultured in L-tyrosine (2.5 mg mL −1 ) with phosphate buffer (pH 6.8, 50 mmol L −1 ). All samples dissolved in DMSO, which is irrelevant to the examination of tyrosinase activity when DMSO constitutes < 0.5% (v/v) of the final working volume.…”

Section: Mushroom Tyrosinase Inhibition Assaymentioning

confidence: 99%

Reversing UVB‐induced photoaging with Hibiscus sabdariffa calyx aqueous extract

Lin

et al. 2019

J Sci Food Agric

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BACKGROUND Hibiscus sabdariffa is commonly used in daily life and its extract is applied widely in food and cosmetics. However, it has not been evaluated for its anti‐aging effects. RESULTS Hibiscus sabdariffa calyx aqueous extract (HSCAE) has shown potential collagenase activity suppression effects, together with tyrosinase activity inhibition, and anti‐oxidation as a free radical scavenger. The current investigation demonstrated that HSCAE was not cytotoxic in skin fibroblasts, and it significantly decreased ultraviolet B (UVB)‐induced reactive oxygen species (ROS) on a flow cytometry assay. Moreover, HSCAE reduced matrix metalloproteinase (MMP) expression, increased tissue inhibition of metalloproteinase (TIMP)‐1 level, and enhanced collagen content by inhibiting collagenase activity. It also blocked mRNA and protein expressions of melanin production pathway key factors, including the microphthalmia‐associated transcription factor (MITF), tyrosinase, tyrosinase‐related protein‐1 (TRP‐1), and dopachrome tautomerase‐2 (TRP‐2). CONCLUSION These results demonstrated, for the first time, the potential of HSCAE as a natural antioxidant with the ability to maintain collagen production and to decrease melanin syntheses under UVB radiation, for anti‐aging effects. © 2019 Society of Chemical Industry

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“…where C 0 is the initial concentration of AST in the nanoemulsion, while C t is the concentration of AST at a specific time interval point. [13,14]. The cytotoxicity of TAP-nanoemulsion was determined by MTT assay.…”

Section: Quantification Of Ast Amount In Tap-nanoemulsionmentioning

confidence: 99%

A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma

Haung

Wang

Cheng

et al. 2020

Oxidative Medicine and Cellular Longevity

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Astaxanthin (AST) is a naturally occurring xanthophyll carotenoid having the potential to be used as an anticancer agent; however, the human body has a low bioavailability of AST due to its poor solubility in the water phase. Therefore, we applied D-α-tocopheryl polyethylene glycol succinate (TPGS) as an emulsifier and natural edible peanut oil to form a steady oil-in-water (O/W) nanoemulsion loaded with AST (denoted as TAP-nanoemulsion). TAP-nanoemulsions were stable without the droplet coalescence against thermal treatments (30-90°C), pH value changes (over a range of 2.0-8.0), and ionic strength adjustments (at NaCl concentrations of 100-500 mM) measured by dynamic light scattering (DLS). AST within TAP-nanoemulsion was released up to 80% in a simulated intestinal enzymatic fluid in vitro, and the overall recovery rate was fairly consistent in the Caco-2 cellular model. In order to further evaluate in vivo melanoma inhibitory experiments, we injected the fluorescent-stained B16F10 cells into female C57BL/6 mouse tail veins and treated TAP-nanoemulsion in an oral gavage. qRT-PCR and Western blot demonstrated that TAP-nanoemulsion triggered effectively the apoptosis pathway, including enhancements of cleaved caspase-3 and caspase-9, ataxia-telangiectasia mutated kinase (ATM), and p21WAF1/CIP1 (p21) and decreases of B-cell lymphoma 2 (Bcl-2); cyclins D, D1, and E; mitogen-activated protein kinase (MEK); extracellular signal-regulated kinases (ERK); nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB); and matrix metallopeptidase-1 and metallopeptidase-9 (MMP-1 and MMP-9) in both gene and protein expressions. In conclusion, this study suggests that TAP-nanoemulsion with the oral treatment has a positive chemotherapy effect in melanoma with lung metastases in vivo. As far as we know, this is the first time to demonstrate that an antioxidant in nanoparticle administration cures lung metastatic melanoma.

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36H: A Novel Potent Inhibitor for Antimelanogenesis

Cited by 17 publications

References 30 publications

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism

Reversing UVB‐induced photoaging with Hibiscus sabdariffa calyx aqueous extract

A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma

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