367 Low English proficiency is associated with decreased biologic access in psoriasis

Abstract

Psoriasis is associated with multiple co-morbid medical conditions. The purpose of this study is to evaluate the relationships between psoriasis and cardiovascular disease, psoriatic arthritis, mental health conditions, and immune-mediated diseases, respectively. A literature search was performed during the study period January 1, 2015 to December 18, 2018. Of 2499 records identified, 28 met our criteria selection and were included in this review. Based on these findings, the relationships between psoriasis and these multiple comorbid disease conditions are discussed. Psoriasis is associated with cardiovascular disease, and chronic inflammation likely plays a major role in this relationship. Treatment of psoriasis improves underlying inflammation and TNF inhibitor therapy may provide a protective effect against risk of MACE for patients with psoriasis, which would ultimately promote better health outcomes for these patients. Additionally, psoriatic arthritis is a common comorbid condition associated with psoriasis that can lead to permanent disability. Early treatment is imperative to help prevent complications of psoriatic arthritis. Autoimmune diseases have also been reported to be associated with psoriasis, which may suggest that the pathogenesis of psoriasis may involve autoimmune mechanisms. Moreover, it is important to address and treat comorbid psychiatric conditions among patients with psoriasis, including depression, suicidal behavior, and suicidal ideation. Early recognition and treatment of comorbid disease conditions is important to consider when developing the treatment plan and overall management of patients with psoriasis to help improve the quality of life for these patients.