362. The dehydration of β-hydroxy-esters

Kon, George Armand Robert; Nargund, K. S.

doi:10.1039/jr9320002461

Cited by 18 publications

(7 citation statements)

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“…The hydroxamate produced from the product migrated as a single spot (RF 0.73) in the above benzene-acetic acidwater system. This material was chromatographically indistinguishable from the hydroxamate derived from the product of dehydration of ethyl 3-hydroxyoctanoate with POC13 (Kon & Nargund, 1932).…”

Section: Preparationsmentioning

confidence: 90%

Intermediates in fatty acid oxidation

Stewart

Tubbs

Stanley

1973

Biochemical Journal

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1. Aqueous extracts of acetone-dried liver and kidney mitochondria, supplemented with NAD(+), CoA and phenazine methosulphate, efficiently convert fatty-acyl-CoA compounds into acetyl-CoA; the process was followed with an O(2) electrode. 2. Label from [1-(14)C]octanoyl-CoA appears in acetyl-CoA more rapidly than that from [8-(14)C]octanoyl-CoA. 3. Oxidation of [8-(14)C]octanoyl-CoA was terminated by addition of neutral ethanolic hydroxylamine and the resulting hydroxamates were separated chromatographically. Hydroxamate derivatives of 3-hydroxyoctanoyl-, hexanoyl-, butyryl- and acetyl-CoA were obtained. 4. These and other observations suggest that oxidation of octanoyl-CoA by extracts involves participation of free intermediates rather than uninterrupted complete degradation of individual molecules to acetyl-CoA by a multienzyme complex. 5. Intact liver mitochondria studied by the hydroxamate technique were also shown to form intermediates during oxidation of labelled octanoates. In addition to octanoylhydroxamate, [8-(14)C]octanoate gave rise to small amounts of hexanoyl-, butyryl- and 3-hydroxyoctanoyl-hydroxamate. In contrast with extracts, however, where the quantity of intermediates found was a significant fraction of the precursors, mitochondria oxidizing octanoate contained much larger quantities of octanoyl-CoA than of any other intermediate.

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Section: Preparationsmentioning

confidence: 90%

Intermediates in fatty acid oxidation

Stewart

Tubbs

Stanley

1973

Biochemical Journal

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“…East Lansing, Michigan Received July 5,1946 [Contribution from the Venable Chemical Laboratory of the University of North Carolina] p-Substituted Phenyl Isothiocyanates and Some Related Thioureas By R. L. McKee1 and R. W. Bost By use of the reaction between primary amines and thiophosgene,2 sulfanilamide, sulfadiazine, sulfaguanidine, sulfacetamide, sulfapyridine and sulfathiazole have been converted into the corresponding isothiocyanates (Table I).…”

Section: Discussionmentioning

confidence: 99%

Isomeric Esters Produced by the Dehydration of Ethyl 3-Hydroxy-2,3-dimethylbutanoate

Huston¹,

Goerner²

1946

J. Am. Chem. Soc.

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“…The phenylhydrazone was obtained as yellow plates which could not be purified. 5 -Fluorosalicylaldehy de (IV).-This compound was prepared by the Reimer-Tiemann reaction using pfluorophenol instead of o-fluorophenol as starting material. To a vigorously stirred solution of 270 g. (6.7 mole) of sodium hydroxide and 110 g. (1.0 mole) of ^-fluorophenol in 890 ml.…”

Section: Rochester New Yorkmentioning

confidence: 99%

Some New Fluorinated Phenolic Aldehydes and Acids

Ferguson¹,

Reid²,

Calvin³

1946

J. Am. Chem. Soc.

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ß-i-Butylaminopropiomtrile.-Acrylonitrile (29 g.) was added dropwise with stirring to 40 g. of redistilled i-butylamine (b. p. 66.5-67.5°). After the addition was complete, the mixture stood for four hours at room temperature, was then refluxed for one hour, and stood overnight. Vacuum distillation yielded only a very small amount of starting material, and 62.97 g. (91%) of product was obtained, b. p. 82-88°( 7 mm.). The analytical sample had the following properties: b. p. 107°( 11 mm.), ra20D 1.4352.

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362. The dehydration of β-hydroxy-esters

Cited by 18 publications

References 0 publications

Intermediates in fatty acid oxidation

Intermediates in fatty acid oxidation

Isomeric Esters Produced by the Dehydration of Ethyl 3-Hydroxy-2,3-dimethylbutanoate

Some New Fluorinated Phenolic Aldehydes and Acids

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