360º optoacoustic capsule endoscopy at 50 Hz for esophageal imaging

Ali, Zakiullah; Zakian, Christian; Li, Qian; Gloriod, Jerome; Crozat, Sophie; Bart, François; Pierre, Guillaume; Sarantos, Vassilis; Pietro, Massimiliano di; Flisikowski, Krzysztof; Andersen, Peter E.; Drexler, Wolfgang; Ntziachristos, Vasilis

doi:10.1016/j.pacs.2022.100333

Cited by 5 publications

(14 citation statements)

References 33 publications

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“…A prototype of such a capsule optoacoustic endoscopy system was built and tested on excised pig esophageal tissue (Figure 2h). 54 For optoacoustic signal generation, the system employed a rapid laser source with a 532 nm wavelength and a repetition rate in the rage of 1−100 kHz, which enabled B-scan frame rates as high as 50 Hz. The illumination was coupled to a multimode optical fiber with a core diameter of 105 μm and a numerical aperture of 0.2.…”

Section: Scopes Placing the Rotating Motor At The Distalmentioning

confidence: 99%

“…This comparison with histology also showed that the vascular morphology of the esophageal wall can be resolved as deep as 2 mm below the surface. Using a higher sensitivity transducer and faster laser source, full 360° FOV imaging of a swine esophagus sample mounted inside a 50 mL falcon tube (Figure b) was also demonstrated . A 3D volume of the esophagus sample was imaged by a pullback scan at 50 Hz B-scan rate over a distance of 12 mm at 2.4 mm/s.…”

Section: Optoacoustic Endoscopy Applicationsmentioning

confidence: 99%

“…This design is challenged by the operational limits of the torque coil with regard to maintaining a consistent rotation speed throughout the examination and achieving the necessary overall rotation speed, due to uncontrolled coil friction producing excessive heat. 56 For example, Furthermore, this design requires a hybrid rotational coupler to pass optical and electrical energy from a stationary system to the rotating endoscope. Such coupling is generally implemented by concentrically aligning a stationary fiber to a rotational fiber and a slip ring to pass electrical (optoacoustic) signals from the rotational unit to a reading system, necessitating precision manufacturing to minimize optical and electrical losses and reduce coupling variations due to rotation.…”

Section: Scopes With Proximal-end Rotationmentioning

confidence: 99%

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Optoacoustic Endoscopy of the Gastrointestinal Tract

Englert

Ntziachristos

2023

ACS Photonics

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Optical endoscopy is the most commonly applied procedure for inspecting the gastrointestinal (GI) tract, and it is based on different approaches and designs, from using a flexible optical scope to swallowing a small camera capsule that obtains photographs as it advances through the digestive tract. Despite its wide use in GI diagnostics and theranostics, optical visualization only allows a superficial inspection of the wall lining (mucosa), therefore limiting the ability to obtain information from deeper GI layers. In the quest for developing methods to visualize under the mucosal layers, we review herein progress with optoacoustic endoscopy, a technique that captures optical contrast in high resolution deep inside tissues, enabling imaging beneath the surface of the mucosa. Optoacoustic endoscopy combines imaging of optical contrast with the resolution and depth penetration afforded by ultrasonography, thus merging highly advantageous characteristics for clinical applications. We review progress and the current status of the technology, its key endoscopic competitors, and challenges for clinical application. We further offer a perspective regarding future directions and the overall application potential of the technique to complement the current state-of-the-art.

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Section: Scopes Placing the Rotating Motor At The Distalmentioning

confidence: 99%

Section: Optoacoustic Endoscopy Applicationsmentioning

confidence: 99%

Section: Scopes With Proximal-end Rotationmentioning

confidence: 99%

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Optoacoustic Endoscopy of the Gastrointestinal Tract

Englert

Ntziachristos

2023

ACS Photonics

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“…Then several PAE/EUS systems with full field-of-view have been proposed by Chen’s group, Song’s group, Xing’s group and Zhu’s group, to visualize the vasculature on colorectum wall in vivo [20] , [21] , [22] , [23] , [24] . Recently, Ntziachristos’s group proposed a capsule endoscopy with outer diameter of 16 mm and imaging speed of video rate of 50 Hz [25] . Although the above-mentioned studies demonstrated the capability of PAE/EUS in acquiring accurate functional and structural information, the hybrid optical and electrical rotary joints in the systems generally brings unexpected issues during high-speed scanning, such as the damage of optical joints by pulsed laser, electrical noise, non-uniform rotation, etc [20] .…”

Section: Introductionmentioning

confidence: 99%

Circular array transducer based-photoacoustic/ultrasonic endoscopic imaging with tunable ring-beam excitation

et al. 2023

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“…Hence, to achieve this goal, photoacoustic endoscopy (PAE) has been developed over these years [ 5 ]. PAE has been employed as a valuable imaging modality in various applications, such as intravascular imaging [ 6 , 7 , 8 , 9 ], genitourinary imaging [ 10 , 11 , 12 , 13 ], esophageal [ 14 , 15 , 16 ], and gastrointestinal imaging [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic/Ultrasound Endoscopic Imaging Reconstruction Algorithm Based on the Approximate Gaussian Acoustic Field

et al. 2022

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This paper aims to propose a new photoacoustic/ultrasound endoscopic imaging reconstruction algorithm based on the approximate Gaussian acoustic field which significantly improves the resolution and signal-to-noise ratio (SNR) of the out-of-focus region. We demonstrated the method by numerical calculations and investigated the applicability of the algorithm in a chicken breast phantom. The validation was finally performed by the rabbit rectal endoscopy experiment. Simulation results show that the lateral resolution of the target point in the out-of-focus region can be well optimized with this new algorithm. Phantom experimental results show that the lateral resolution of the indocyanine green (ICG) tube in the photoacoustic image is reduced from 3.975 mm to 1.857 mm by using our new algorithm, which is a 52.3% improvement. Ultrasound images also show a significant improvement in lateral resolution. The results of the rabbit rectal endoscopy experiment prove that the algorithm we proposed is capable of providing higher-quality photoacoustic/ultrasound images. In conclusion, the algorithm enables fast acoustic resolution photoacoustic/ ultrasonic dynamic focusing and effectively improves the imaging quality of the system, which has significant guidance for the design of acoustic resolution photoacoustic/ultrasound endoscopy systems.

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360º optoacoustic capsule endoscopy at 50 Hz for esophageal imaging

Cited by 5 publications

References 33 publications

Optoacoustic Endoscopy of the Gastrointestinal Tract

Optoacoustic Endoscopy of the Gastrointestinal Tract

Circular array transducer based-photoacoustic/ultrasonic endoscopic imaging with tunable ring-beam excitation

Photoacoustic/Ultrasound Endoscopic Imaging Reconstruction Algorithm Based on the Approximate Gaussian Acoustic Field

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