(360) Can CBD Reduce the Use of Pain Medication? Lessons from a Survey in a Pain Clinic Environment

Moeller-Bertram, Tobias; Schilling, Jan M.; Hughes, Chloe G; Wallace, Meredith; Sexton, Margaret; Backonja, Misha-Miroslav

doi:10.1016/j.jpain.2019.02.056

Cited by 2 publications

(7 citation statements)

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“…The results of this study suggest that using CBD-rich hemp extract oil may help reduce opioid use and improve quality of life, specifically in regards to pain and sleep, among chronic pain patients. This is consistent with emerging literature on the topic, which has concluded that CBD is an effective analgesic, and one that helps reduce barriers to opioid reduction, such as physiological withdrawal symptoms [22][23][24][25][26][27][28][29][30][31]. Recently, Wiese et al summarized the evidence for different used of the cannabinoids with opioids [13].…”

Section: Discussionsupporting

confidence: 78%

“…Additional studies showed significant improvement in pain symptoms using CBD as augmentation for opioids [9,[25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Preclinical models demonstrate CBD's ability to decrease relapse risk by reducing opioid seeking behavior [24]. Early human trials confirm CBD's potential in reducing opioid withdrawal symptoms [25]. A recent survey study concluded that 44% of hemp CBD users reported it helped reduce the use of their opioid pain medication [25].…”

Section: Introductionmentioning

confidence: 99%

“…Early human trials confirm CBD's potential in reducing opioid withdrawal symptoms [25]. A recent survey study concluded that 44% of hemp CBD users reported it helped reduce the use of their opioid pain medication [25]. CBD was found to reduce the craving, anxiety and psychological manifestations significantly in drug-abstinent individuals with previous opioid dependency [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

Capano¹,

Weaver

Burkman

2019

Postgraduate Medicine

112

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Context: Chronic pain is highly prevalent in most of the industrialized nations around the world. Despite the documented adverse effects, opioids are widely used for pain management. Cannabinoids, and specifically Cannabidiol, is proposed as an opioid alternative, having comparable efficacy with better safety profile. Objectives: We aim to investigate the impact of full hemp extract cannabidiol (CBD) on opioid use and quality of life indicators among chronic pain patients. Methods: An initial sample of 131 patients was recruited from a private pain management center's investigative population. Ninety-seven patients completed the 8-week study. The primary inclusion criteria included patients between 30 and 65 years old with chronic pain who have been on opioids for at least 1 year. Data were collected at three different time points: baseline, 4, and 8 weeks. Opioid and other medication use were evaluated via the medication and psychiatric treatment receipt. Improvement was evaluated using four indices: Pain Disability Index (PDI-4); Pittsburgh Sleep Quality Index (PSQI), Pain Intensity and Interference (PEG); and Patient Health Questionnaire (PHQ-4). Results: Over half of chronic pain patients (53%) reduced or eliminated their opioids within 8 weeks after adding CBD-rich hemp extract to their regimens. Almost all CBD users (94%) reported quality of life improvements. The results indicated a significant relationship between CBD and PSQI (p = 0.003), and PEG (p = 0.006). There was a trend toward improvement but no significant relationship between CBD use and PHQ and PDI. Conclusion: CBD could significantly reduce opioid use and improve chronic pain and sleep quality among patients who are currently using opioids for pain management. Key Message: This is a prospective, single-arm cohort study for the potential role of cannabinoids as an alternative for opioids. The results indicate that using the CBD-rich extract enabled our patients to reduce or eliminate opioids with significant improvement in their quality of life indices. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 78%

“…Additional studies showed significant improvement in pain symptoms using CBD as augmentation for opioids [9,[25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

Capano¹,

Weaver

Burkman

2019

Postgraduate Medicine

112

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“…The questionnaire was designed based on the outline of survey creation described by Passmore et al ( 2002 ). Additionally, previously published literature using surveys for CBD research were referenced (Corroon et al 2018 , Bhamra et al 2021 , Moltke et al, Schilling et al 2021 , Moeller-Bertram et al 2019 , Devitt 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study

et al. 2022

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Introduction An estimated 54 million Americans currently suffer from debilitating arthritis. Patients who have exhausted conservative measures can be subject to chronic pain and resort to symptomatic management with anti-inflammatories, acetaminophen, and opioids. Cannabidiol (CBD) is a non-psychoactive cannabinoid that has shown promise in preclinical studies to reduce inflammation and pain associated with arthritis. The purpose of this study was to explore patient perceived effects of cannabidiol on symptoms of arthritis. Methods A novel anonymous questionnaire was created to evaluate perceived efficacy of cannabidiol for the treatment of arthritis. A self-selected convenience sample (N=428) was recruited through online methods including social media accounts and newsletters (The Arthritis Foundation and Savvy Cooperative) between May 5, 2020, and November 5, 2020. Statistical analysis was performed to determine differences between types of arthritis and improvements in quality-of-life symptoms. Furthermore, a regression analysis was performed to identify variables associated with decreasing or discontinuing other medications. Results CBD use was associated with improvements in pain (83%), physical function (66%), and sleep quality (66%). Subgroup analysis by diagnosis type (osteoarthritis, rheumatoid, or other autoimmune arthritis) found improvements among groups for physical function (P=0.013), favoring the osteoarthritis group. The overall cohort reported a 44% reduction in pain after CBD use (P<0.001). The osteoarthritis group had a greater percentage reduction (P=0.020) and point reduction (P<0.001) in pain compared to rheumatoid arthritis and other autoimmune arthritis. The majority of respondents reported a reduction or cessation of other medications after CBD use (N=259, 60.5%): reductions in anti-inflammatories (N=129, 31.1%), acetaminophen (N=78, 18.2%), opioids (N=36, 8.6%) and discontinuation of anti-inflammatories (N=76, 17.8%), acetaminophen (N=76, 17.8%), and opioids (N=81, 18.9%). Conclusion Clinicians and patients should be aware of the various alternative therapeutic options available to treat their symptoms of arthritis, especially in light of the increased accessibility to cannabidiol products. The present study found associations between CBD use and improvements in patient’s arthritis symptoms and reductions in other medications. Future research should focus on exploring the benefits of CBD use in this patient population with clinical trials.

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(360) Can CBD Reduce the Use of Pain Medication? Lessons from a Survey in a Pain Clinic Environment

Cited by 2 publications

References 0 publications

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study

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