36 Autoimmune Thyroiditis Associated With Metabolic Syndrome in Postmenopausal Women

Костіцька, І. О.; Babenko, Ilona

doi:10.1016/s0378-5122(12)70147-0

Cited by 1 publication

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“…Enhancement of antibodies to thyroid tissue production may be due to the fact that elevation of leptin level is accompanied by a predominance of cell-mediated immune responses, due to increased production of cytokines by T-helpers type 1 against the background of decreased functional ability of T-suppressors and an increased number of natural killers (NK-cells) in obese patients with type 2 DM [5,12]. Such changes in the immune system lead to thyrocytes alterations and apoptosis development and are characteristics of autoimmune thyroiditis [13,17].…”

Section: Resultsmentioning

confidence: 99%

Peculiarities of Antithyroid Autoimmunity Indicators in Type 2 Diabetic Patients Depending on Leptin Level in Blood Serum and Their Dynamics as a Result of Sodium Selenite Treatment

Abramova

Pashkovska

Berezova

2021

Mìžnarodnij endokrinologìčnij žurnal

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There were studied 46 patients with diabetes mellitus type 2 in order to identify the autoimmune processes directed against thyroid tissue and dependence of those changes on the level of leptin in blood serum. It was established that in patients with high leptin serum level antithyroid antibody titer increased. In order to adjust the levels of antithyroid antibodies sodium selenite was prescribed against the background of standard therapy. Statistically significant reduction in antibodies expression to thyroglobulin and thyroperoxidase after treatment with sodium selenite dosed 50 mg after a month has been found.

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Section: Resultsmentioning

confidence: 99%