36. Age-dependent kinetics and metabolism of dichloroacetate: Possible relevance to toxicity

Shroads, Albert L.; Xu, Guowang; Dixit, Vaishali; Liu, Huiping; James, Margaret O.; Stacpoole, Peter W.

doi:10.1016/j.mito.2008.12.032

Cited by 1 publication

(1 citation statement)

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“…It has been reported that DCA metabolism could be gender- and sex hormone dependent in rats: activity of glycolate oxidase in gonad-intact females and gonadectomized male rats was significantly lower than in gonad-intact males ones (glycolate oxidase is involved in the conversion of DCA metabolite glycolic acid to oxalate in rat liver); testosterone increases and estrogens decrease activity of glycolate oxidase in male rats [68]. The preclinical studies of DCA metabolism were conducted only in male rats [69–74]. Data on DCA metabolism in males cannot be directly extrapolated to females.…”

Section: Discussionmentioning

confidence: 99%

Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall’s Corpuscles and RNA NKCC1 Expression in Rat Thymus

Stanevičiūtė

Juknevičienė

Balnytė

et al. 2019

BioMed Research International

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The aim was to investigate the effect of dichloroacetate (DCA) on thymus weight, Hassall’s corpuscle number (HCs), and NKCC1 RNA expression in Wistar rats aged 4–5 weeks. They were investigated in the controls and DCA-treated gonad-intact and castrated males and females. The treatment lasted 4 weeks with DCA 200 mg/kg/day. At the end of the experiment, rat thymus was weighted, and its lobe was taken for the expression of NKCC1 RNA determined by the PCR method and of Hassall’s corpuscles by immunohistochemistry. DCA caused a thymus weight decrease in DCA-treated gonad-intact rats of both genders as compared with their controls (p < 0.05), and no such impact was found in castrated DCA-treated males and females. DCA caused an increase of the HCs in gonad-intact males (p < 0.05), and no such increase in the DCA-treated gonad-intact females was found. There was gender-related difference in the HCs when comparing DCA-treated gonad-intact males and females: males showed significantly higher HCs (p < 0.05); no gender-related differences were found in the castrated DCA-treated groups. The Slc12a2 gene RNA expression level was found to be significantly decreased only in gonad-intact and in castrated DCA-treated males. The authors discuss the gender-related DCA effects on the thymus.

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Section: Discussionmentioning

confidence: 99%