359 Program cell death-1-ligand 1 blockade leads to MHC class I dependent IL-17 response in cocultures of CLA+/ epidermal cells activated by Streptococcal pyogenes in psoriasis
Abstract:Bullous pemphigoid (BP) is the most common autoimmune blistering disease caused by autoantibodies to hemidesmosomal proteins; type XVII collagen (COL17 or BP180) and BP230. Regulatory T cells (Tregs) are crucial for peripheral immune tolerance and maintaining cutaneous immune homeostasis. However, it remains largely unknown whether failure of peripheral immune tolerance has an influence on the production of autoantibodies to the epidermal components. To address this, we investigated scurfy mice, which lack fun… Show more
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