354. Genetically Modified Human Mesenchymal Stromal Cell (MSC) Delivery Improved Glucose Tolerance in Diet Induced Obese (DIO) Mouse Models

Domingues, Cleyton C.; Kundu, Nabanita; Ahmadi, Neeki; Sen, Sabyasachi

doi:10.1016/s1525-0016(16)33163-x

Cited by 2 publications

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“…Additionally, injecting via intrasplenic route was found to be more effective at reversing hyperglycemia than the intrapancreatic route in a STZ-induced diabetic mouse model [45]. The effects of upregulation of other antioxidants on MSCs to treat diabetes in different high fat diet induced obese diabetic mouse models are under investigation in our laboratory [46].…”

Section: Mesenchymal Stromal Cellsmentioning

confidence: 98%

Genetic Modification of Stem Cells in Diabetes and Obesity

Domingues¹,

Kundu²,

Dore³

et al. 2016

Genetic Engineering - An Insight Into the Strategies and Applications

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Genetic modification, or gene transfer, represents a method of treatment for several diseases. It has been used extensively in the context of cardiovascular diseases; however, its role in the context of metabolic diseases, such as diabetes and obesity, has remained largely unexplored. In this chapter, we will review the use of adult stem cells, focusing on endothelial progenitor cells (EPCs) and mesenchymal stromal cells (MSCs), in the context of diabetes. We have highlighted the use of viral vectors, particularly DNA viruses, as a tool for genetic modification to help stem cells survive and resist apoptosis in a hyperglycemic environment. We then discuss genetic modification of EPCs and MSCs to treat complications of diabetes and obesity. Although there are several unanswered questions in the field of metabolic diseases, the future application of gene transfer technology along with genetic modification of stem cells prior to the therapy holds significant therapeutic promise.

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Section: Mesenchymal Stromal Cellsmentioning

confidence: 98%