353 Coffee consumption and clinical outcomes in colombian patients with systemic lupus erythematosus

Alzate, MA; Ochoa, F. Perez; Ortiz-Salazar, P; Hernandez-Parra, D.; Pineda, Raymundo

doi:10.1136/lupus-2017-000215.353

Cited by 2 publications

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“…32 Regarding disease activity, in Colombian SLE patients, coffee consumption was positively associated with 6 months clinical remission. 33 Furthermore, the metabolomic profile in the serum of active SLE patients was characterized by the down-regulation of some metabolites including caffeine. 34 Our results are in line with these data, showing the possible impact of caffeine on SLE disease activity, as demonstrated by the inverse correlation between intake of caffeine and SLEDAI-2K.…”

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confidence: 99%

Caffeine intake influences disease activity and clinical phenotype in systemic lupus erythematosus patients

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Ceccarelli

Barbati

et al. 2020

Lupus

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Objective Caffeine, one of the most widely consumed products in the world, seems to interact with multiple components of the immune system by acting as a non-specific phosphodiesterase inhibitor. In vitro dose-dependent treatment with caffeine down-regulates mRNA levels of key inflammation-related genes in peripheral blood mononuclear cells. So far, no robust data are available about the possible contribution of caffeine in systemic lupus erythematosus (SLE). The aim of this study was to evaluate the impact of caffeine consumption on SLE-related disease phenotype and activity, in terms of clinimetric assessment and cytokine serum levels. Methods We performed a cross-sectional study, enrolling consecutive patients and reporting their clinical and laboratory data. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2K). Caffeine intake was evaluated by a 7-day food frequency questionnaire, including all the main sources of caffeine. As previously reported, patients were divided into four groups according to the daily caffeine intake: <29.1 mg/day (group 1), 29.2–153.7 mg/day (group 2), 153.8–376.5 mg/day (group 3) and >376.6 mg/day (group 4). At the end of questionnaire filling, blood samples were collected from each patient to assess cytokine levels. These were assessed by using a panel by Bio-Plex assays to measure the levels of IL-6, IL-10, IL-17, IL-27, IFNγ, IFNα and BLyS. Results We enrolled 89 consecutive SLE patients. We observed a negative correlation between caffeine consumption and disease activity, measured with SLEDAI-2K. A significantly higher prevalence of lupus nephritis, neuropsychiatric involvement, haematological manifestations, hypocomplementaemia and anti-dsDNA positivity was observed in patients with a low intake of caffeine. Furthermore, patients with a low intake of caffeine were more frequently treated with glucocorticoids. Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNγ was found ( p = 0.03, r = –0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNα ( p = 0.02), IL-17 ( p = 0.01) and IL-6 ( p = 0.003). Conclusions In this report we demonstrated the impact of caffeine on SLE disease activity status, as confirmed by the inverse correlation between its intake and both SLEDAI-2K values and cytokine levels. Moreover, patients with a low caffeine consumption seem to have a more severe disease phenotype.

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Section: Discussionmentioning

confidence: 99%

Caffeine intake influences disease activity and clinical phenotype in systemic lupus erythematosus patients

Orefice

Ceccarelli

Barbati

et al. 2020

Lupus

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“…Our results are concordant with a previous published study evaluating a Colombian SLE cohort, in which coffee consumption was positively associated with 6 months clinical remission. 10 Moreover, Kiyohara and colleagues analysed the association between coffee intake and SLE risk, demonstrating only a marginal dose-dependent association. 11 …”

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The Impact of Caffeine Intake on Patients with Systemic Lupus Erythematosus: Protect Yourself, Drink More Coffee!

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Ceccarelli

Barbati

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353 Coffee consumption and clinical outcomes in colombian patients with systemic lupus erythematosus

Abstract: Table 1 Sociodemographic and clinical characteristics of the SLE patients Abstract 353 Table 2 Association between coffee consumption and clinical outcomes in SLE patients (N=731)

Cited by 2 publications

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Caffeine intake influences disease activity and clinical phenotype in systemic lupus erythematosus patients

Caffeine intake influences disease activity and clinical phenotype in systemic lupus erythematosus patients

The Impact of Caffeine Intake on Patients with Systemic Lupus Erythematosus: Protect Yourself, Drink More Coffee!

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