352 Longitudinal Infusion of Insulin-Like Growth Factor-I and Igf-Binding Protein-3 Complex to Five Preterm Infants - Pharmacokinetics and Short Term Safety

Abstract

Abstracts also expressed by the gastric mucosa and pancreatic β-cells) in fetal samples from LGA and appropriate-for-gestational-age-(AGA) pregnancies and study their association with gender, parity, and delivery mode. Methods Cord blood nesfatin-1 concentrations were prospectively measured by enzyme-linked immunosorbent assay in 40 LGA (9 born from diabetic mothers and 31 born from non-diabetic mothers) and 20 AGA singleton full-term infants.Results Cord blood nesfatin-1 concentrations were lower in LGA compared to AGA neonates, after controlling for confounding factors (b= -0.206, p=0.005, SE 0.07). However, cord blood nesfatin-1 concentrations were elevated in infants born from mothers presenting with gestational diabetes mellitus (GDM), compared to those born from non-diabetic mothers, after controlling for group (b=0.190, p=0.050, SE 0.10). Finally, cord blood nesfatin-1 concentrations were lower in cases of vaginal delivery (b=0.11, p=0.042, SE 0.05). Conclusions Down-regulation of nesfatin-1 in LGA fetuses probably represents a negative feedback exerted by adipose tissue on nesfatin-1 production. On the other hand, fetal nesfatin-1 concentrations are higher in cases of GDM, probably indicating the possible involvement of nesfatin-1 in the regulation of insulin secretion from pancreatic β-cells. Finally, vaginal delivery-associated inflammation could probably account for lower cord blood nesfatin-1 concentrations.