3508 Preventive effect of traditional Japanese medicine on neurotoxicity of FOLFOX for metastatic colorectal cancer: a multicenter retrospective study

Hosokawa, Ayumu; Kajiura, Shinya; Kobayashi, Yuka; Ogawa, Kiyoshi; Saito, Sumiko; Tsukioka, Yuji; Kobayashi, Tomoe; Horikawa, Naoki; Sawasaki, Kunihiro; Sugiyama, Toru

doi:10.1016/s1359-6349(09)70696-2

Cited by 22 publications

(32 citation statements)

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“…Reduces peripheral neuropathy without influence on anti-cancer potency Ameliorates abnormal sensations and histological damage to the sciatic nerve [41,42] Paclitaxel in mice Inhibits mechanical allodynia [43] Oxaliplatin in a placebo-controlled double-blind randomized study Delays onset of grade 2 or greater peripheral neurotoxicity without impairing FOLFOX efficacy with an acceptable safety margin [44,45] Prevents exacerbation of peripheral neuropathy [46,47] A clinical trial enrolling 82 patients Reduces peripheral neuropathy [48] …”

Section: Oxaliplatin In Ratsmentioning

confidence: 99%

“…A Kaplan-Meier analysis showed that Jesengsingi-Hwan could prevent exacerbation of oxaliplatin-induced peripheral neuropathy [46]. Hosokawa et al assessed the preventive properties of Jesengsingi-Hwan on oxaliplatin-induced neurotoxicity in colorectal cancer patients and found that in the Jesengsingi-Hwan-treated group, 50% of oxaliplatin-induced peripheral neuropathy was prevented without diminishing chemotherapy efficacy [47].…”

Section: Jesengsingi-hwan (Goshajinkigan In Japanese)mentioning

confidence: 99%

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Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Lee

Kim

2016

Molecules

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Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient's quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted to seek alternative treatment options since there is no conventional remedy for CIPN. A range of medicinal herbs have multifarious effects, and they have shown some evidence of efficacy in various neurological and immunological diseases. While CIPN has multiple mechanisms of neurotoxicity, these phytomedicines might offer neuronal protection or regeneration with the multiple targets in CIPN. Thus far, researchers have investigated the therapeutic benefits of several herbs, herbal formulas, and phytochemicals in preventing the onset and progress of CIPN in animals and humans. Here, we summarize current knowledge regarding the role of phytochemicals, herb extracts, and herbal formulas in alleviating CIPN.

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Section: Oxaliplatin In Ratsmentioning

confidence: 99%

Section: Jesengsingi-hwan (Goshajinkigan In Japanese)mentioning

confidence: 99%

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Lee

Kim

2016

Molecules

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“…These results found 6 single herbs [238,245,[287][288][289][290][291][292][293][294][295][296], one extract [297], one 2-107 receptor agonist [298,299] and 8 combinations of herbs [300][301][302][303][304][305][306][307][308][309][310][311][312][313][314][315][316][317][318]. All studies were analysed for common scientific characteristics however lower levels of evidence was used as rigorous randomised clinical trials were limited.…”

Section: Herbal Medicine and Cipnmentioning

confidence: 99%

“…The primary endpoint was the incidence of grade 2 CIPN or greater before the 8 th cycle. Two studies human studies have been conducted on this formula, a retrospective case analysis [302] and a retrospective clinical trial comparison [306]. The retrospective case analysis investigated 23 patients with paclitaxel-IPN and observed that this combination had a positive effect on the neuropathic pain experienced by these ovarian cancer patients [302].…”

Section: Goshajinkigan (Japan) Niu Che Sen Qi Wan (Chinese) Pilula mentioning

confidence: 99%

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A pilot clinical trial assessing the efficacy and safety of supplementation with a B complex vitamin to reduce the incidence of chemotherapy induced peripheral neuropathy in patients diagnosed with a malignancy

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Effect of Shakuyaku‐kanzo‐to in patients with muscle cramps: A systematic literature review

Ota

Fukui

Nakamura

et al. 2020

J of Gen and Family Med

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Background Previous clinical studies have reported that Shakuyaku‐kanzo‐to (SKT) has a therapeutic effect on muscle cramps, but few studies have clarified how SKT acts to treat muscle cramps. The aim of this study was to perform an updated systematic review of clinical trials for SKT in patients with muscle cramps. Methods The literature was systematically reviewed to assess the effects of SKT in patients with muscle cramps. PubMed, Web of Science, Cochrane Library, Google Scholar, and Ichushi‐Web were searched using the terms “Shakuyaku‐kanzo‐to” (“shakuyakukanzoto”, etc), “clinical trials” and “muscle cramps”. Two quality assessments were conducted independently by three authors. Data were extracted using a standardized extraction tool, and a qualitative synthesis of evidence was performed. Results Three randomized controlled articles were identified and enrolled in this study. A systematic review, but not a meta‐analysis, was performed because of the high heterogeneity and limited number of studies. In patients with liver cirrhosis, the odds ratio (OR) for improvement with SKT compared to placebo was 1.27 (95% confidence interval [CI], 0.445‐2.086) and compared to Goshajinkigan was 0.81 (95%CI, −1.734‐0.114). The OR for improvement with SKT compared with eperisone hydrochloride in patients with lumbar spinal stenosis was 2.86 (95%CI, 0.980‐4.744). Conclusions Current evidence appears insufficient to allow a meta‐analysis of the effects of SKT, but SKT might show efficacy in treating muscle cramps in patients with cirrhosis or lumbar spinal stenosis.

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3508 Preventive effect of traditional Japanese medicine on neurotoxicity of FOLFOX for metastatic colorectal cancer: a multicenter retrospective study

Cited by 22 publications

References 0 publications

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

A pilot clinical trial assessing the efficacy and safety of supplementation with a B complex vitamin to reduce the incidence of chemotherapy induced peripheral neuropathy in patients diagnosed with a malignancy

Effect of Shakuyaku‐kanzo‐to in patients with muscle cramps: A systematic literature review

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