35 Role of Cxcl4 Chemokine in Angiogenic Activity of Non-Small Cell Lung Cancer (Nsclc)

Špaks, Artjoms; Isajeva, Darja; Spaka, Irina; Pirtnieks, Ainis; Jaunalksne, Inta; Grusina-Ujumaza, Jelena; Basko, Jazeps; Taivāns, Immanuels; Krieviņš, Dainis

doi:10.1016/s0169-5002(13)70256-3

Cited by 1 publication

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“…On the other hand, other available studies have shown that CXCL1 expression is decreased in NSCLC tumors [129,130]. Serum levels of CXCL1 are also increased in lung adenocarcinoma patients relative to healthy subjects [126], although another study shows that patients with early-stage NSCLC have lower levels of circulating CXCL1 than healthy subjects [131].…”

Section: Lung Cancermentioning

confidence: 96%

The Clinical Significance and Involvement in Molecular Cancer Processes of Chemokine CXCL1 in Selected Tumors

Korbecki,

Bosiacki,

Szatkowska

et al. 2024

IJMS

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Chemokines play a key role in cancer processes, with CXCL1 being a well-studied example. Due to the lack of a complete summary of CXCL1’s role in cancer in the literature, in this study, we examine the significance of CXCL1 in various cancers such as bladder, glioblastoma, hemangioendothelioma, leukemias, Kaposi’s sarcoma, lung, osteosarcoma, renal, and skin cancers (malignant melanoma, basal cell carcinoma, and squamous cell carcinoma), along with thyroid cancer. We focus on understanding how CXCL1 is involved in the cancer processes of these specific types of tumors. We look at how CXCL1 affects cancer cells, including their proliferation, migration, EMT, and metastasis. We also explore how CXCL1 influences other cells connected to tumors, like promoting angiogenesis, recruiting neutrophils, and affecting immune cell functions. Additionally, we discuss the clinical aspects by exploring how CXCL1 levels relate to cancer staging, lymph node metastasis, patient outcomes, chemoresistance, and radioresistance.

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