347P Histamine blockade with loratadine for prevention of granulocyte-colony stimulating factor (G-CSF)-associated bone pain: A meta-analysis

Abstract

thromboembolism (PTE) in 3 (3.8%) patients. Also, out of all, 43 (53.8%) patients belonged to the low risk category of Khorana score, while 37 (46.2%) patients were in the intermediate category. There was no significant association between Khorana scores obtained and VTE (fisher exact test, p-value ¼ 0.171).

Can loratadine help in treating granulocyte-colony stimulating factor-induced bone pain?

“…6,9,13 A meta-analysis found that patients taking loratadine reported less bone pain (57% compared with 60% in the control group), although the difference was not statistically signifi cant. 14 Despite limited studies and lack of guidelines, loratadine has been recommended off-label for relief of G-CSFinduced bone pain when conventional methods of pain relief are either contraindicated or unsatisfactory.…”

“…Cases of G-CSF-induced bone pain being treated with once-daily loratadine 10 mg have been reported, but the available literature exploring this use is limited 6,9,13. A meta-analysis found that patients taking loratadine reported less bone pain (57% compared with 60% in the control group), although the difference was not statistically significant 14…”