Divergent dynamics in systemic and tissue-specific metabolic and inflammatory responses during weight loss in subjects with obesity

Velde, Frederique Van de; Ouwens, D.M.; Batens, Arsène-Hélène; Nieuwenhove, Yves Van; Lapauw, Bruno

doi:10.1016/j.cyto.2021.155587

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…Exclusion criteria were the presence of malignancies, drinking more than two units (women) or three units (men) of alcohol per day, having known liver pathologies other than non-alcoholic fatty liver disease. For the current analysis, five samples with NAS score 0 or 1 were selected ( 60 ).…”

Section: Methodsmentioning

confidence: 99%

Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats and humans

Stede¹,

Spaas²,

Jager³

et al. 2023

Preprint

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Histidine-containing dipeptides (HCDs) are pleiotropic homeostatic molecules linked to inflammatory, metabolic and neurological diseases, as well as exercise performance. Using a sensitive UHPLC-MS/MS approach and an optimized quantification method, we performed a systematic and extensive profiling of HCDs in the mouse, rat, and human body (in n=26, n=25, n=19 tissues, respectively). Our data show that tissue HCD levels are uniquely regulated by carnosine synthase, an enzyme preferentially expressed by fast-twitch skeletal muscle fibers and brain oligodendrocytes. Cardiac HCD levels are remarkably low. The low abundant HCD N-acetylcarnosine is enriched in human skeletal muscles. Here, N-acetylcarnosine is continuously secreted into the circulation as the most stable plasma HCD, which is further induced by acute exercise in a myokine-like fashion. Carnosine is preferentially transported within red blood cells in humans but not rodents. We provide a novel basis to unravel tissue-specific, paracrine, and endocrine roles of HCDs in human health and disease.

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Section: Methodsmentioning

confidence: 99%

Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats and humans

Stede¹,

Spaas²,

Jager³

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Exclusion criteria were the presence of malignancies, drinking more than two units (women) or three units (men) of alcohol per day, having known liver pathologies other than non‐alcoholic fatty liver disease. For this analysis, five samples with NAS score 0 or 1 were selected 68 …”

Section: Methodsmentioning

confidence: 99%

“…For this analysis, five samples with NAS score 0 or 1 were selected. 68 4.2.7 | Human plasma and RBC Blood samples were always collected in pre-cooled EDTA tubes, after a 1-2-day lacto-ovo vegetarian diet to ensure no influence of dietary HCD intake. For plasma, samples were immediately centrifuged (10 min, 3000 × g, 4°C), followed by immediate deproteinization (110 μL of 35% 5-sulfosalisylic acid per 1 mL of plasma) and second centrifugation (5 min, 15 000 × g, 4°C).…”

Section: Human Livermentioning

confidence: 99%

Extensive profiling of histidine‐containing dipeptides reveals species‐ and tissue‐specific distribution and metabolism in mice, rats, and humans

Van der Stede,

Spaas,

de Jager

et al. 2023

Acta Physiologica

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Elevated Interleukin-6 Is Associated with Successful Weight Loss 3 Months Postlaparoscopic Sleeve Gastrectomy

Bracha,

Jaroch,

Falkowski

et al. 2024

OBES SURG

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Purpose Bariatric surgery poses an ever-increasing importance in the effective and long-lasting treatment of obesity, a condition strongly associated with inflammation and increased risk of other diseases and health problems. In obesity-related inflammation, maintaining a balance between pro-inflammatory and anti-inflammatory cytokines is crucial. In this study, we examined early effects of laparoscopic sleeve gastrectomy (LSG) on inflammatory and anti-inflammatory cytokines in obese patients, and assessed their effect on postoperative weight loss. Materials and Methods This prospective cohort study was conducted from September 2022 till June 2023. Fifty obese adults were enrolled for LSG. All patients underwent assessments of body measurements, as well as levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and TNF-alpha at baseline and 3 months postsurgery. We developed a decision tree model to predict the success of weight loss. Results At 3 months postsurgery, patients lost 18.9 ± 6.9 kg of excess body weight. A significant decrease was observed for IL-10 (p < 0.0001), simultaneously with a significant increase in IL-6 (p < 0.0001). We found that high IL-6 (> 1.169 pg/mL) levels could contribute to an effective weight loss among patients with a baseline BMI less than 47.46 kg/m2. Conclusion Study revealed that 3 months after bariatric surgery, inflammation persists, and its markers significantly influence postoperative weight loss, as indicated by BMI range. Distinct behaviors of IL-10 and IL-6 in relation to obesity underline the necessity of considering individual cytokine profiles when evaluating bariatric surgery outcomes. Graphical Abstract

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Divergent dynamics in systemic and tissue-specific metabolic and inflammatory responses during weight loss in subjects with obesity

Cited by 4 publications

References 46 publications

Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats and humans

Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats and humans

Extensive profiling of histidine‐containing dipeptides reveals species‐ and tissue‐specific distribution and metabolism in mice, rats, and humans

Elevated Interleukin-6 Is Associated with Successful Weight Loss 3 Months Postlaparoscopic Sleeve Gastrectomy

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