Placental Site Trophoblastic Tumor in a Pulmonary Vascular Malformation With Spontaneous Pneumothorax

Chinthareddy, Rohan Reddy; Muthirevula, Arvind; Rajan, V; Srikrishna, S. V.; Lingaraju, Vijay Cholenahalli

doi:10.1016/j.athoracsur.2021.04.098

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…This situation becomes more complicated when PSTT is found in extrauterine sites. Extrauterine PSTTs have been reported in multiple locations including ovary [ 15 , 16 ], fallopian tube [ 15 , 17 , 18 ], pelvic wall [ 19 ], vagina [ 20 ], pouch of Douglas [ 21 ], and lung [ 22 , 23 ]. Traditionally classified as a gestational trophoblastic neoplasm, extrauterine PSTT is thought to arise from an ectopic pregnancy or as a metastasis from a uterine PSTT [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian non-gestational placental site trophoblastic tumor with lung metastasis: further evidence for a distinct category of trophoblastic neoplasm

Shahi,

Katsakhyan,

Hopkins

et al. 2024

Diagn Pathol

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We previously described a series of cases which characterize a distinct group of primary ovarian placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) as a non-gestational set consistent with germ cell type/origin. Here we report a new case of ovarian non-gestational PSTT. The patient was a 13 year-old young female admitted for a spontaneous pneumothorax of the left lung. The pathology of lung wedge excision specimen demonstrated metastatic PSTT and ovarian biopsy showed atypical intermediate trophoblastic proliferation which was found to be PSTT in the subsequent salpingo-oophorectomy specimen. In the ovary, the tumor was composed of singly dispersed or small clusters of predominantly mononuclear cells and rare multinucleated cells extensively infiltrating the ovarian parenchyma, tubal mucosa, and paraovarian/paratubal soft tissue. A minor component of mature cystic teratoma (less than 5% of total tumor volume) was present. Immunohistochemically, the neoplastic cells of main tumor were diffusely immunoreactive for hPL, Gata3 and AE1/AE3, and had only rare hCG-positive or p63-positive cells. The morphology and immunohistochemical results support a PSTT. Molecular genotyping revealed an identical genotype pattern between the normal lung tissue and the metastatic PSTT, indicating its non-gestational nature of germ cell type/origin. This case represents the first case of such tumor with distant (lung) metastasis. This case also provides further evidence to support our recommendation that primary ovarian non-gestational intermediate trophoblastic tumors of germ cell type/origin, including PSTT and ETT, should be formally recognized in classification systems.

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Section: Discussionmentioning

confidence: 99%

Ovarian non-gestational placental site trophoblastic tumor with lung metastasis: further evidence for a distinct category of trophoblastic neoplasm

Shahi,

Katsakhyan,

Hopkins

et al. 2024

Diagn Pathol

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“…Choriocarcinoma as an etiology for PAP was reported in Singapore ( Wee et al, 2017 ). A case of PAVM in the setting of GTN presenting with PTX was reported in 2022 ( Chinthareddy et al, 2022 ). Rarer still, however, are reports on acute pulmonary events that occur in the setting of chemotherapy initiation.…”

Section: Discussionmentioning

confidence: 99%

Acute pulmonary complications in the setting of high risk gestational trophoblastic neoplasia and induction of chemotherapy

Khadraoui

Herzog

Jackson

et al. 2023

Gynecologic Oncology Reports

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“…11 Rarely, pneumothorax is the initial presentation. 8,12 Pulmonary artery pseudoaneurysms 10,13 and pulmonary arteriovenous malformations 12,14 were also reported.…”

Section: Abstract Cystic Lung Lesions Diffuse Lung Disease Lung Cysts...mentioning

confidence: 99%

An unusual case of metastatic trophoblastic neoplasm presenting with diffuse cystic lung disease and pulmonary artery pseudoaneurysms in a teenager

Guler,

Hull,

Arteta

et al. 2024

Pediatric Pulmonology

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Diffuse cystic lung diseases (DCLDs) are a diverse group of lung disorders characterized by the presence of multiple air filled cysts within the lung tissue. These cysts are thin walled and surrounded by normal lung tissue. In adults, DCLD can be associated with various conditions such as lymphangioleiomyomatosis (LAM), Langerhans cell histiocytosis, cancers, and more. In children, DCLD is often linked to lung developmental abnormalities, with bronchopulmonary dysplasia being a common cause. Patients with pulmonary cysts are typically asymptomatic, but some may experience mild symptoms or pneumothorax. While DCLD in children is rarely due to malignancy, metastatic lung disease can be a cause. It is important for clinicians to be aware of the possibility of metastatic lung disease when encountering DCLD.

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Placental Site Trophoblastic Tumor in a Pulmonary Vascular Malformation With Spontaneous Pneumothorax

Cited by 3 publications

References 4 publications

Ovarian non-gestational placental site trophoblastic tumor with lung metastasis: further evidence for a distinct category of trophoblastic neoplasm

Ovarian non-gestational placental site trophoblastic tumor with lung metastasis: further evidence for a distinct category of trophoblastic neoplasm

Acute pulmonary complications in the setting of high risk gestational trophoblastic neoplasia and induction of chemotherapy

An unusual case of metastatic trophoblastic neoplasm presenting with diffuse cystic lung disease and pulmonary artery pseudoaneurysms in a teenager

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